Cell death programs such as apoptosis and ferroptosis are associated with aberrant redox homeostasis linked to lipid metabolism and membrane function. Evidence for cross-talk between these programs is emerging. Here, we show that cytotoxic stress channels polyunsaturated fatty acids via lysophospholipid…
Huge phenotype heterogeneities of cancer cells contribute to the development of cancer stem cells (CSC) which mediate stem-like properties and contribute to the formation of multi drug resistance (MDR). However, since toxicities of available treatments is often dose limiting, the escape of resistant…