In tumor cells, interleukin-6 (IL-6) signaling can lead to activation of the epidermal growth factor receptor (EGFR), which prolongs Stat3 activation. In the present experiments, we tested the hypothesis that IL-6 signaling activates EGFR signaling in peripheral and spinal nociception and examined whether…
Previous years showed that in clinically relevant pain states a process of spinal neuroinflammation develops which is characterized by the activation of spinal astroglia and microglia and is involved in pain generation by induction of central sensitization (spinal hyperexcitability). Spinal glial cells…