Leukotrienes are pro-inflammatory lipid mediators generated by 5-lipoxygenase aided by the 5-lipoxygenase-activating protein (FLAP). BRP-201, a novel benzimidazole-based FLAP antagonist, inhibits leukotriene biosynthesis in isolated leukocytes. However, like other FLAP antagonists, BRP-201 fails to effectively…
Cham (ZG): Springer International Publishing, 2021-12-31
Polymers are malleable materials that offer multiple design possibilities, and as such, they are frequently used to fabricate highly customized nanocarriers for drug delivery applications. Among the most crucial technological advantages of polymer-based drug delivery systems are: (i) They can be engineered…