Abstract This study explores protein‐loaded, semipermeable polymer capsules for potential applications in drug delivery and biomedical analytics. Several proteins were loaded into mesoporous silica particles and encapsulated by layer‐by‐layer (LbL) assembling of oppositely charged polyelectrolytes. The…
Aerogels are nanostructured materials of high porosity and high specific surface area. While the first cellulose II aerogels were made about 20 years ago, practically nothing is known about the influence of the degree of substitution of cellulose ethers and esters on aerogel properties. Model hydrophobic…
Hygrophila ringens var. ringens is a medicinal plant of the Acanthaceae family. A soluble polysaccharide is extracted from H. ringens seeds using warm water, followed by deproteinization and purification using column chromatography. DL1 is characterized comprehensively using spectroscopic and chromatographic…
This study presents the synthesis of allyl-functionalized polysaccharide carbamates (AFCs) with tailored water solubility designed for use in responsive hydrogels and 3D printing applications. A modular one-pot approach was employed to produce cellulose- and xylan-based AFCs, utilizing polysaccharide…
The chemical modification of polysaccharides plays a central role in the development of advanced materials, especially in biomedicine and drug delivery. Modular synthesis approaches enable the targeted structuring and multifunctionalization of polysaccharide materials by using primary and secondary hydroxyl…
To exploit the full potential of these naturally occurring biopolymers, they can be chemically modified. In particular, the hydroxy group, which occurs in all polysaccharides, can be functionalised. Most common reaction is esterification, and less frequently etherification (primarily technical products…
The layer-by-layer (LbL) assembling of oppositely charged polyelectrolytes was studied using semi-synthetic polysaccharide derivatives, namely the polycations 6-aminoethylamino-6-deoxy cellulose (ADC) and cellulose (2-(ethylamino)ethylcarbamate (CAEC), as well as the polyanion cellulose sulfate (CS).…
The goal of this study was to explore a route for introducing functionalities into agarose-based hydrogels to tune the physical, chemical, and biological properties. Several agarose derivatives were prepared by homogeneous synthesis, including anionic agarose sulfates (ASs), reactive azido agaroses (AZAs),…
An efficient and easy‐to‐use approach is presented for obtaining biocompatible polysaccharide‐based nanoparticles (NP) that can act as tumor‐specific drug delivery agents. Two antibodies are directly immobilized onto reactive xylan phenyl carbonate (XPC) NP; namely Cetuximab (CTX) that binds to human…
Hydrogelmaterialien sind in unserem täglichen Leben allgegenwärtig und finden in verschiedenen Produkten Anwendung. Weiche Kontaktlinsen, Bandagen, Windeln, Wundauflagen, Gesichtsmasken oder Markennamen wie Voltaren®, Pampers® und Hylaform® sind nur einige Beispiele dafür die vielfältigen Bereiche, in…
RNA interference can be applied to different target genes for treating a variety of diseases, but an appropriate delivery system is necessary to ensure the transport of intact siRNAs to the site of action. In this study, cellulose was dually modified to create a non-viral vector for HDAC3 short interfering…
Im Rahmen dieser Arbeit wurden zunächst neuartige ionische Agarosederivate synthetisiert und anschließend umfassend charakterisiert. Anionische Agarosesulfate mit einer regioselektiven Derivatisierung in Position G6 wurden durch homogene Umsetzung in ionischer Flüssigkeit erhalten. Kationische Agarosecarbamate…
Die vorliegende Forschungsarbeit beschreibt die Synthese und Reaktivität substituierter Bis(pyrazol-1-yl)methanid-Komplexe der s-Blockmetalle und des Zinks. Mit dem C-Homoskorpionat HC(PzMe,Me)3 (3a) und der Hauser-Base [MgBr{N(SiMe3)2}]2 wird das Magnesat [{CH(PzMe,Me)3}Mg{C(PzMe,Me)3}]+[(thf)MgBr{N(SiMe3)2}2]-…
Polygalacturonic acid hydrazide (PGH) is one of only a few polysaccharide derivatives with pronounced nucleophilic characteristics known today. This water‐soluble and benign material could be reacted with the hydrophilic aldehydes D ‐glucose in water, without any catalyst and at room temperature, resulting…
Methyl cellulose and its derivatives are widely used in the food industry, cosmetics, and as construction materials. The properties of methyl celluloses (MC) strongly depend on their degrees and positions of substitution. In order to generate MCs with uncommon blocky substitution, we apply fully protected…
Abstract Composite nanoparticles (NPs) consisting of lignin and different polysaccharide (PS) derivatives were prepared. In this synergistic approach, the PS derivative acts as biocompatible matrix that forms spherical NPs while lignin is a functional compound with therapeutic potential (e.g., antioxidative,…
Hydrophobe Wirkstoffe weisen häufig eine schlechten Bioverfügbarkeit und Transporteffizienz auf. Diese Nachteile können durch ein optimiertes Nanoträgersystem kompensiert werden. Hierfür sind polymerbasierte Mizellen und Nanopartikel mit einem hydrophoben Kern besonders geeignet. Die Personalisierung…
A comprehensive description and comparison of present market dissolving wood pulps (DWP) is provided. The systematic difference between kraft and sulfite pulps destined for the same application could be shown. Alkalization or alkaline extraction is the most common process operation when using DWP. A…
Polysaccharide (PS) based nanoparticles (NP) are of great interest for biomedical applications. A key challenge in this regard is the functionalization of these nanomaterials. The aim of the present work was the development of reactive PS-NP that can be coupled with an amino group containing compounds…
Die Auswirkungen verschiedener Synthesemethoden auf die Struktur der daraus entstehenden Stärkeester und die daraus resultierenden Eigenschaften wurden untersucht.