55 Dokumente gefunden
Design and Structural Characterization of Ferrocenyl Bithiophene Thioketone-Based Iron Complexes
The exceptional catalytic efficiency of [FeFe]-hydrogenases has driven intense efforts to reproduce their structure and function in synthetic models. A key structural feature governing the behavior of synthetic H-cluster analogs lies in the identity of the bridging dithiolato ligands that link the iron…
Basel: MDPI, 2025-12-28
Engineered [FeFe]-hydrogenase mimics featuring heteroaryl linkers: molecular design and photocatalytic hydrogen evolution…
Inspired by the active site of [FeFe]-hydrogenase, we have developed synthetic mimics engineered from the reaction of heteroaryl thioketone derivatives ferrocenyl(5-(4-(diphenylamino)phenyl)thiophen-2-yl)methanethione ( PS-Fc-1 ), ferrocenyl(5′-(4-(diphenylamino)phenyl)-[2,2′-bithiophen]-5-yl)methanethione…
Cambridge: The Royal Society of Chemistry, 2025-09-10
Selective Light‐Driven CO 2 to CO Reduction by a [FeFe]‐Hydrogenase Mimic in Water
Abstract We report a biomimetic system for light‐driven CO 2 conversion in lipid bilayers using a [FeFe]‐hydrogenase‐inspired molecular dyad ( PS‐CAT ) acting simultaneously as photosensitizer and catalyst. The molecular design of PS‐CAT consists of both light‐harvesting and catalytically active moieties…
Weinheim: Wiley-VCH, 2025-07-11
Synthesis and Electrochemical Investigations of a Binuclear [FeFe]‐Hydrogenase Mimic
aus: ChemElectroChem
Herein, a [FeFe]‐hydrogenase mimic with the benzene‐1,2‐dithiolato ligand bearing two amino groups in 4‐ and 5‐position of the ligand is reported. The ligand synthesis is straight forward and accomplished in two steps. Detailed studies show that the implementation of the functional groups in the [FeFe]‐hydrogenase…
Weinheim: Wiley-VCH, 2025-06-11
Die Mögliche Entstehung des Lebens in einer Eisen-Schwefel-Welt
Wie alt ist das Leben auf unserem Planeten? Wie wahrscheinlich ist die Bildung von Lebensformen unter den Bedingungen der frühen Erde? Welche Voraussetzungen werden dazu gebraucht? Waren die ersten Zellen einfacher als heutige Organismen? Ist die Evolution abgeschlossen? Bevor wir aber versuchen, den…
Jena: Friedrich-Schiller-Universität, 2025-02-22
Electrochemical and photocatalytic characterization of [FeFe]-hydrogenase mimics for hydrogen production
This dissertation provides novel insights and advancements in the dynamic research area of [FeFe]-hydrogenase mimics, addressing various facets through distinct subtopics. Following the synthesis and characterization of diiron complexes designed to replicate the H-cluster of natural [FeFe]-hydrogenase…
Halogen bonding for the design of functional materials
This thesis investigates the potential of σ-hole halogen bonds (XBs) as supramolecular interactions for developing functional materials. XBs are highly tunable and linear, making them ideal for applications such as anion recognition, sensing, catalysis, and polymer design. The work focuses on design…
Synthesis and investigation of [FeFe] hydrogenase mimics
Diese Arbeit liefert neue Erkenntnisse auf dem aktuellen Forschungsgebiet der [FeFe] H2ase Modellkomplexe, wobei jeder Artikel seinen eigenen Schwerpunkt hat. Nach der Synthese und Charakterisierung der Dieisen-Komplexe, die den H Cluster natürlicher [FeFe] H2ase-Enzyme nachahmen, wurde eine Funktionalisierung…
Synthetic Approaches towards Peptide‐Conjugates of Pt(II) Compounds with an ( O , S ) Chelating Moiety
Metal‐containing peptide (bio−)conjugates have received continuous interest due to their enormous potential for bioinorganic and medicinal research. In many bioconjugates the chemical inertness of the metal‐containing units facilitates synthesis e. g. by copper‐catalyzed alkyne−azide cycloaddition or…
Weinheim: Wiley-VCH, 2023-12-20
Templated Total Synthesis of Cu(I)‐Methanobactin OB3b **
Abstract Methanobactin OB3b (Mbn‐OB3b) is a unique natural product with stunning affinity for copper ions ( K a ≈Cu(I) 10 34 ). Here, we report the first total synthesis of Cu(I)‐bound methanobactin OB3b featuring as key transformations a cyclodehydration‐thioacylation sequence, to generate the conjugated…
Weinheim: Wiley, 2023-10-09
Multi-action platinum(IV) prodrugs conjugated with COX-inhibiting NSAIDs
In the last decades, inflammation has been recognized as being closely connected to cancer, and joint strategies encompassing chemotherapeutic and anti-inflammatory agents have been extensively studied. In this work, a series of novel cisplatin and oxaliplatin-based Pt(IV) complexes comprising non-steroidal…
Amsterdam [u.a.]: Elsevier BV, 2023-09-05
Synthesis of [FeFe] Hydrogenase Mimics with Lipoic acid and its Selenium Analogue as Anchor Groups
[FeFe] hydrogenase (H 2 ase) mimicking complexes containing lipoic and selenolipoic acid moieties connected to 2‐hydroxy‐1,3‐dithiopropane and 2‐hydroxy‐1,3‐diselenopropane bridging ligands were synthesized and characterized using different spectroscopic methods. X‐ray diffraction analysis was utilized…
Weinheim: Wiley-VCH, 2023-04-03
Novel Homoleptic and Heteroleptic Pt(II) β‐oxodithiocinnamic ester Complexes: Synthesis, Characterization, Interactions with…
Abstract Three new series of homoleptic and heteroleptic platinum(II) β‐oxodithiocinnamic ester complexes, [Pt(L1–L9) 2 ], [Pt(L1–L9)(DMS)Cl] and [Pt(L1–L9)(DMSO)Cl], were synthesized and characterized using elemental analysis, mass spectrometry, and different NMR spectroscopy ( 1 H, 13 C{ 1 H} and 195…
[FeFe] hydrogenase mimics : access and activation
Im Hinblick auf eine nachhaltige Energiewirtschaft könnte „grüner“ Wasserstoff (H2) aus der Wasserspaltung mithilfe erneuerbarer Energien mittelfristig eine geeignete Alternative zu fossilen Energieträgern darstellen. Eine solche Perspektive wäre ohne H2-Grundlagenforschung undenkbar, bei der ein Blick…
Platinum(IV) complexes as prospective anticancer agents : synthesis, characterization, and biological evaluation
In recent decades, Pt(II)-based chemotherapy drugs, such as cisplatin, oxaliplatin, and carboplatin, have been among the most effective drugs for cancer treatment. They have been widely used in various malignant solid tumors, including lung cancer, colorectal cancer, testicular cancer, ovarian cancer,…
Reactivity of platinum (II) complexes with (O,S) bidentate ligands towards DNA model systems for cancer treatment
The FDA-approved platinum(II) drugs cisplatin, carboplatin, and oxaliplatin, are the mainstays of present chemotherapy regimens. Nevertheless, there are a variety of severe side effects, including nephrotoxicity, neurotoxicity, ototoxicity, and nausea as well as the problems of drug resistance and dosage…
A Remarkable Ring Opening Observed in the Reaction of Cyclopropyl Ferrocenyl Thioketone with Triiron Dodecacarbonyl Fe 3…
In continuation of the study focused on synthesis and structure of mimics of the active site of the [FeFe] hydrogenase enzyme, reaction of Fe 3 (CO) 12 with cyclopropyl ferrocenyl thioketone 1 was carried out. Two different complexes with ring‐opened cyclopropyl fragments were isolated and identified…
Weinheim: Wiley-VCH, 2022-12-19
Facile Synthesis and Characterization of Pure Tochilinite‐like Materials from Nanoparticulate FeS
Abstract In this work, three different tochilinite‐like materials have been obtained by sophisticated synthetic methods that allow to control the distribution of iron ions. The purity of the samples was confirmed by powder X‐ray diffraction. From elemental analysis and Mössbauer spectroscopy data, detailed…
Dual Function of β ‐Hydroxy Dithiocinnamic Esters: RAFT Agent and Ligand for Metal Complexation
Abstract The reversible addition‐fragmentation chain‐transfer (RAFT) process has become a versatile tool for the preparation of defined polymers tolerating a large variety of functional groups. Several dithioesters, trithiocarbonates, xanthates, or dithiocarbamates have been developed as effective chain…
Weinheim: Wiley, 2022-11-04
Oxoplatin‐Based Pt(IV) Lipoate Complexes and Their Biological Activity
α‐Lipoic acid, known for its anti‐inflammatory and antioxidant activity, represents a promising ligand for Pt(IV) prodrugs. Three new Pt(IV) lipoate complexes were synthesized and characterized by NMR spectroscopy ( 1 H, 13 C, 195 Pt), mass spectrometry and elemental analysis. Due to the low solubility…
Zürich: Wiley-Blackwell, 2022-08-26