Background/Objectives : The revolution for the treatment of melanoma came with the approval of checkpoint blockade antibodies. However, a substantial proportion of patients show primary or secondary resistance to this type of immunotherapy, indicating the need for alternative therapeutic strategies.…
Since the success of solid organ transplants, such as human kidneys, livers and hearts, from the 50s to the 60s in the last century, the field of organ transplantation has progressed rapidly. Mainly due to modifications in surgical operation techniques and improvements in immunosuppressive therapy regimes,…
Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic…
Univerbation is the syntagmatic condensation of a sequence of words recurrent in discourse into one word, as when the Spanish combination a tras (to back) becomes atrás ‘behind’. It affects both lexemes and grammatical formatives. Unlike processes of word formation, including conversion of a syntactic…
Dendritic cells (DCs) are professional antigen-presenting cells of the immune system. Upon sensing pathogenic material in their environment, DCs start to mature, which includes cellular processes, such as antigen uptake, processing and presentation, as well as upregulation of costimulatory molecules…
This is a dissertation on the Kanakanavu language, i.e. that linguistic phenomena found while working on the language underwent a deeper analysis and linguistic techniques were used to provide data and to present analyses in a structured manner. Various topics of the Kanakanavu language system are exemplified:…
Abstract Parts of speech have both semantic and structural aspects. The two sets of features are essentially incommensurate, since the semantic features derive from the functions of language in communication and cognition, while the structural features are essentially based in the combinatorial potential…
Die vorliegende Arbeit leistet, auf Grundlage der Diskussion bisheriger
sprachkompetenztheoretischer Ansätze, einen Beitrag zur Herausstellung der Bedeutung der
Variationskompetenz als systemkompetenzunabhängige Komponente von Sprachkompetenz
sowie deren empirischer Bestimmung. Der Fokus liegt hierbei…
Abstract The categorization alluded to in the title is the assignment of a class of concepts to a lexeme class and/or a syntactic category. The purpose of the paper is to establish converseness of strategies of categorization among languages as a typological concept. It is argued that, quite in general,…
Einige Gebrauchstexte wie etwa Briefwahlunterlagen, Sicherheitshinweise und Beipackzettel für
Medikamente müssen für die gesamte erwachsene Bevölkerung verständlich sein. Dennoch gelten
gerade sie als eher schlecht zu verstehen. Als Ursache ist unter anderem denkbar, dass solche Texte
oft zahlreiche…
Die vorliegende Arbeit leistet einen Beitrag zur theoretischen und empirischen Bestimmung des
Begriffes der linguistischen Begabung. Der Begriff Begabung wird im Rahmen der
Begabungsforschung aus unterschiedlichen Blickwinkeln beleuchtet und eine Begriffsdefinition
deduziert, anhand derer sich auch…