Pseudomonas syringae is a soil‐dwelling bacterium that exhibits remarkable niche adaptability, and it is known for its devastating impact as a plant pathogen. This bacterium has an outstanding capability to produce a wide array of biologically active natural products. P. syringae coexists with amoebal…
Covering: 2011 to 2025 The importance of redox cofactors like nicotinamide adenine dinucleotide or flavin adenine dinucleotide as cofactors for enzymatic reactions in living organisms is widely known. However, many microbial species also employ unusual redox cofactors such as the coenzyme F 420 or the…
Published: The Royal Society of Chemistry, 2025-05-16
Influenza A virus (IAV) infections continue to threaten public health. Current strategies, such as vaccines and antiviral drugs, are limited due to their time-consuming development and drug-resistant strains. Therefore, new effective treatments are needed. Here, virus-supportive cellular factors are…
Ziel dieser Arbeit war die Synthese von sekundären Phosphanchalkogeniden, insbesondere den Sulfiden und Seleniden, deren Alkalimetallsalzen und Oxidationsverbindungen, den Phosphinaten, sowie die Darstellung von gemischtvalenten P(III)-P(V)-Verbindungen. Zur Synthese der Phosphansulfide und -selenide…
Ziel dieser Arbeit war die Entwicklung neuartiger Methoden zur Addition sekundärer Phosphanoxide an Alkine unter s-Block-Metallkatalyse. Mit 5 mol-% Kaliumhexamethyldisilazanid [K(hmds)] reagiert Dimesitylphosphanoxid bei Raumtemperatur rasch und regioselektiv mit Phenylacetylen zum β-Additionsprodukt.…
Tuberkulose ist die tödlichste bakterielle Infektionskrankheit, die durch einen einzigen Erreger, das Bakterium Mycobacterium tuberculosis, verursacht wird. Sie war im Jahr 2022 für den Tod von 1,5 Millionen Menschen verantwortlich. Die Standardtherapie von Tuberkulose besteht aus einer sechsmonatigen…
The most common problem in enantioselective Lewis base catalyzed reactions is the typically narrow scope for the nucleophilic reaction partner. It was hypothesized that this problem can be addressed using latent nucleophiles, derivatives of otherwise nucleophilic molecules which are not nucleophilic…
Picolines and quinaldines are valuable building blocks and intermediates in the synthesis of natural products and pharmaceuticals. Functionalization of the methyl group in picolines and quinaldines under mild conditions is challenging. We report that the concept of latent pronucleophiles enables Lewis…
Cambridge: The Royal Society of Chemistry, 2024-08-03
Heteroarylphosphonium salts are easily accessible, versatile intermediates in functionalization of N‐heterocycles. Direct C−C bond formation by net substitution of the phosphine has so far required transition metal catalysts, the use of strongly basic reagents or redox catalysis. Here we describe a C−C…
Trifluoro‐ and trichloroacetamides serving as pronucleophiles undergo enantioselective Lewis base catalyzed N ‐allylation with Morita‐Baylis‐Hillman carbonates to produce enantioenriched β‐amino acid derivatives. The reactions proceed as a kinetic resolution to give the allylation products and the remaining…
NHC-Borane verfügen über ein großes Potential für Anwendungen in der organischen Synthese in Form vielseitiger Reaktionspartner und Katalysatoren. Besonders vielversprechend für zukünftige Anwendungen sind hierbei reaktive Zwischenstufen, wie NHC-stabilisierte Borkationen und Borylanionen, welche aus…
In dieser Dissertation wurde die Koordinationschemie von N-mesityl-P,P-diphenylphosphinamid (HL) in Gegenwart der s-Blockmetalle M = Li, Mg, Ca, Sr und Ba untersucht. Unter Anwendung der Schlenk-Technik, konnten 12 neue N-mesityl-P,P-diphenylphosphinimidat Komplexe aus THF, Toluen, 1,2-Dimethoxyethan…
Lewis base catalyzed allylations of C‐centered nucleophiles have been largely limited to the niche substrates with acidic C−H substituted for C−F bonds at the stabilized carbanionic carbon. Herein we report that the concept of latent pronucleophiles serves to overcome these limitations and allow for…
The formation of C−C bonds via the allylation of carbonyl compounds has been widely applied in total syntheses. Amongst the many possible strategies, the Barbier‐type allylation in aqueous media has received only moderate attention over the last decades despite its mild reaction conditions. In this study,…
The research in this thesis focuses predominately on the preparation and characterization of polymers and block copolymers containing ionizable or charged moieties. In the first part of this thesis, the synthesis and polymerization of various monomers is described, which are converted into polyelectrolytes…
The aim of this thesis was to develop solutions to overcome the common problem related to nucleophile scope in Lewis base catalyzed reactions and develop new synthetic methods and generate new knowledge and deeper understanding of these processes. Relying on the strategies used in previous Lewis base…
The muscle-type nicotinic acetylcholine receptors (nAChRs) are expressed at the neuromuscular junction, where they mediate the fast-synaptic response upon acetylcholine (ACh) release from motor neurons. The nAChR is one of the most studied ion channels and its gating mechanism has been described intensively.…