79 Dokumente gefunden
Folge 1: Warum Frauen häufiger an Entzündungen leiden und Männer stärker unter Schnupfen
Prof. Oliver Werz forscht in der Pharmazeutischen Chemie an der Universität Jena zu Entzündungsprozessen im menschlichen Körper. Dabei konnte er bereits 2005 nachweisen, dass es zentrale Geschlechtsunterschiede zwischen Männern und Frauen gibt. Wir sprechen mit Oliver Werz u.a. darüber, warum die Entwicklung…
Jena: Friedrich-Schiller-Universität, 2026-01-30
Unveiling the molecular dynamics of a nitrile-containing 5-lipoxygenase-activating protein antagonist in primary macrophages…
aus: Chemical Science
The nitrile (–C 00000000000000000 00000000000000000 00000000000000000 01111111111111110 00000000000000000 01111111111111110 00000000000000000 01111111111111110 00000000000000000 00000000000000000 00000000000000000 N) functional group is a versatile pharmacophore motif that also serves as an intrinsic,…
Erschienen: The Royal Society of Chemistry, 2026-01-09
Matching drug and polymer for efficient delivery of anti-inflammatory drugs : PLGA , polyesteramides, and acetalated dextran
The hydrochalcone derivative MF-15 and the synthetically derived BRP-201 are potent anti-inflammatory active pharmaceutical ingredients (APIs) that suffer from poor bioavailability. This necessitates their incorporation into drug delivery systems. To address this limitation, we investigated four polymeric…
London: The Royal Society of Chemistry, 2025-10-16
Enhanced Efficiency of the Microsomal Prostaglandin E 2 Synthase‑1 Inhibitor AGU661 in Human Whole Blood by Encapsulation…
Microsomal prostaglandin E 2 synthase 1 (mPGES-1) is a promising target for treating chronic inflammatory diseases and pain. The novel benzimidazole derivative AGU661 exhibits strong potency as a mPGES-1 inhibitor in a cell-free assay of prostaglandin E 2 (PGE 2 ) formation with IC 50 = 0.22 nM. Comprehensive…
Washington: American Chemical Society, 2025-10-03
Modifications in FLAP 's second cytosolic loop influence 5‐ LOX interaction, inhibitor binding, and leukotriene formation
aus: FEBS Letters
Leukotrienes, synthesized via the 5‐lipoxygenase (5‐LOX) pathway in the arachidonic acid cascade, are critical in inflammation. Effective leukotriene production requires interaction between 5‐LOX and 5‐LOX‐activating protein (FLAP) at the nuclear membrane. This study used site‐directed mutagenesis to…
High-fat diet impairs microbial metabolite production and aggravates influenza A infection
Abstract Background Alterations in the gut microbiom can significantly impact various regions in the human body, including the pulmonary tract. This study investigates alterations in the gut microbiome during a high-fat diet (HFD), particularly short-chain fatty acids (SCFAs), and how these metabolites…
London: BioMed Central, 2025-07-31
Enhancing tofacitinib’s therapeutic efficacy in murine arthritis with a synbiotic formulation comprising Bacillus megaterium…
Introduction Omega-3 polyunsaturated fatty acids (n3-PUFA) are known for their anti-inflammatory benefits, particularly in chronic conditions like rheumatoid arthritis (RA). To resolve an acute inflammation, conversion of n3-PUFA into specialized pro-resolving mediators (SPM) is crucial. Recently, it…
Lausanne: Frontiers Media S.A., 2025-05-26
Anti-Influenza Activity of 6BIGOE: Improved Pharmacological Profile After Encapsulation in PLGA Nanoparticles
Influenza A virus (IAV) infections continue to threaten public health. Current strategies, such as vaccines and antiviral drugs, are limited due to their time-consuming development and drug-resistant strains. Therefore, new effective treatments are needed. Here, virus-supportive cellular factors are…
Basel: Molecular Diversity Preservation International, 2025-04-29
Bacillus megaterium DSM 32963 Enhances Specialized Pro-Resolving Mediator Production from an n -3 PUFA Salt in a Dynamic…
aus: Metabolites
Background: Omega-3 polyunsaturated fatty acids ( n -3 PUFA) have been used in the treatment of inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), and their effects are potentiated upon conversion to specialized pro-resolving mediators (SPM). Recent studies indicated that the probiotic…
Basel: MDPI, 2025-02-07
Identification of novel anti-inflammatory drugs for nanoparticle-assisted modulation of the eicosanoid biosynthetic pathway
Increasing life expectancy and an aging population contribute to a higher prevalence of inflammatory diseases requiring long-term treatment. Conventional anti-inflammatory drugs such as NSAIDs or COX-2 inhibitors reduce pro-inflammatory lipid mediators but also suppress essential physiological ones,…
Combination of phosphatidylcholine-bound polyunsaturated fatty acids with cytoskeleton-targeting drugs for overcoming tumor…
Huge phenotype heterogeneities of cancer cells contribute to the development of cancer stem cells (CSC) which mediate stem-like properties and contribute to the formation of multi drug resistance (MDR). However, since toxicities of available treatments is often dose limiting, the escape of resistant…
Einführung digitaler Prozesse im Krankenhaus unter klinisch-pharmazeutischen Gesichtspunkten
Mit Hilfe des Krankenhauszukunftsgesetzes wird die Etablierung eines durchgängig digitalen Medikationsmanagements, auch Closed Loop Medication Management (CLMM) genannt, unterstützt. Die Basis stellt das Elektronische Medikationssystem (EMS) dar. Auf Basis dieser Daten können die Medikamente der Patient:innen…
Regulation of macrophage function through cytoskeletal remodeling by Sirt7 and Miz1
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a major global health challenge. Macrophages play a key role in controlling Mtb infection, yet Mtb can evade or disrupt their defenses. I found reduced SIRT7 and MIZ1 expression in the peripheral blood of TB patients, with deficiencies…
The Fatal Mushroom Neurotoxin Muscarine is Released from a Harmless Phosphorylated Precursor upon Cellular Injury
l ‐(+)‐Muscarine ( 1 )‐producing mushrooms pose a severe threat to human health as ingestion can result in circulatory collapse or even death. However, their metabolic profile is surprisingly poorly understood, including knowledge of poison release and potentially toxic congeners. In the mycelium of…
Weinheim: Wiley, 2024-11-19
Aspergillus fumigatus ‐derived gliotoxin impacts innate immune cell activation through modulating lipid mediator production…
Gliotoxin (GT), a secondary metabolite and virulence factor of the fungal pathogen Aspergillus fumigatus , suppresses innate immunity and supports the suppression of host immune responses. Recently, we revealed that GT blocks the formation of the chemotactic lipid mediator leukotriene (LT)B 4 in activated…
Erschienen: Wiley-Blackwell, 2024-11-03
Unveiling the power of liquid chromatography in examining a library of degradable poly(2-oxazoline)s in nanomedicine applications…
A library of degradable poly(2-alkyl-2-oxazoline) analogues (dPOx) with different length of the alkyl substituents was characterized in detail by gradient elution liquid chromatography. The hydrophobicity increased with increased side chain length as confirmed by a hydrophobicity row, established by…
London: The Royal Society of Chemistry, 2024-10-17
Synthesis and Biological Activity Assessment of 2-Styrylbenzothiazoles as Potential Multifunctional Therapeutic Agents
A current trend in healthcare research is to discover multifunctional compounds, able to interact with multiple biological targets, in order to simplify multi-drug therapies and improve patient compliance. The aim of this work was to outline the growing demand for innovative multifunctional compounds,…
Basel: MDPI, 2024-10-01
Alkyne-tagged imidazolium-based membrane cholesterol analogs for Raman imaging applications †
aus: Chemical Science
Cholesterol is an important lipid playing a crucial role in mediating essential cellular processes as well as maintaining the basic structural integrity of biological membranes. Given its vast biological importance, there is an unabated need for sophisticated strategies to investigate cholesterol-mediated…
Erschienen: The Royal Society of Chemistry, 2024-08-07
Charakterisierung des Adapterproteins FAM159B
FAM159B ist ein bisher nur wenig untersuchtes Adapterprotein mit unbekannter Funktion. Die verfügbare Literatur beschreibt eine Expression im Pankreas und in den neuroendokrinen Zellen des Magens. Das Protein soll in der Zellmembran und im Zytosol lokalisiert sein. Es wird eine Rolle bei der Regulation…
Sex hormone deprivation abolishes sex‐specific differences in murine colon inflammation and related lipid mediator production
aus: The FASEB Journal
Abstract Unresolved inflammation, due to unfavorable imbalances between pro‐inflammatory and pro‐resolving mediators, leads to chronic inflammatory pathologies that are often sex‐biased and regulated by sex hormones, including inflammatory bowel disease. Lipid mediators (LM) produced from polyunsaturated…
Hoboken (New Jersey): Wiley, 2024-07-22