54 documents found

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Toxic effect of C60 fullerene-doxorubicin complex towards tumor and normal...

Creation of new nanostructures possessing high antitumor activity is an important problem of modern biotechnology. Aim. To evaluate cytotoxicity of created complex of pristine C60 fullerene with the anthracycline antibiotic doxorubicin (Dox), as well as of free C60 fullerene and Dox, towards different...
Kyiv: Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, 2019-06-18
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Complex of C60 fullerene with doxorubicin as a promising agent in antitumor...

The main aim of this work was to evaluate the effect of doxorubicin in complex with C60 fullerene (C60 + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C60 + Dox complex action. We found that volume of tumor from mice...
New York, NY [u.a.]: Springer, 2015-12-29
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C60 fullerene prevents genotoxic effects of doxorubicin in human lymphocytes...

The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (С60+Dox) was evaluated...
Kylv: Naukova Dumka, 2015-01
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C60 fullerene as synergistic agent in tumor-inhibitory Doxorubicin treatment

Background: Doxorubicin (Dox) is one of the most potent anticancer drugs, but its successful use is hampered by high toxicity caused mainly by generation of reactive oxygen species. One approach to protect against Dox-dependent chemical insult is combined use of the cytostatic drug with antioxidants....
Auckland: Springer International, 2014-12-12
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C60 fullerene effect on the dynamics of fatigue processes in rat soleus...

Effect of pristine C60 fullerene aqueous colloid solution (C60FAS; 1 mg/kg dose) on the dynamics of fatigue processes in rat soleus muscle after ischemia-reperfusion injury using the tensiometric method was studied. Experiments were conducted during the first 5 h and for 5 days after ischemia. The changes...
Article / Chapter
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Effect of fullerene C60 on ATPase activity and superprecipitation of skeletal...

Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit...
Kylv: Naukova Dumka, 2013-03
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Proceedings of the 14th Joint International IMEKO TC1 + TC7 + TC 13 Symposium

Table of Contents with links to the conference papers.