5 documents found

Article / Chapter
CC BY 4.0
2019-06-18

Toxic effect of C60 fullerene-doxorubicin complex towards tumor and normal...

Creation of new nanostructures possessing high antitumor activity is an important problem of modern biotechnology. Aim. To evaluate cytotoxicity of created complex of pristine C60 fullerene with the anthracycline antibiotic doxorubicin (Dox), as well as of free C60 fullerene and Dox, towards different...
Kyiv: Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, 2019-06-18
Article / Chapter
CC BY 4.0
2018-10-31

C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating...

Background: C60 fullerene-based nanoformulations are proposed to have a direct toxic effect on tumor cells. Previous investigations demonstrated that C60 fullerene used alone or being conjugated with chemotherapeutic agents possesses a potent anticancer activity. The main aim of this study was to investigate...
Wien: Springer, 2018-10-31
Article / Chapter
CC BY 4.0
2015-12-29

Complex of C60 fullerene with doxorubicin as a promising agent in antitumor...

The main aim of this work was to evaluate the effect of doxorubicin in complex with C60 fullerene (C60 + Dox) on the growth and metastasis of Lewis lung carcinoma in mice and to perform a primary screening of the potential mechanisms of C60 + Dox complex action. We found that volume of tumor from mice...
New York, NY [u.a.]: Springer, 2015-12-29
Article / Chapter
CC BY 4.0
2015-01

C60 fullerene prevents genotoxic effects of doxorubicin in human lymphocytes...

The self-ordering of C60 fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60 fullerene (С60+Dox) was evaluated...
Kylv: Naukova Dumka, 2015-01
Article / Chapter
CC BY 4.0
2013-03

Effect of fullerene C60 on ATPase activity and superprecipitation of skeletal...

Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit...
Kylv: Naukova Dumka, 2013-03