Die Leber ist als zentrales Stoffwechselorgan des Organismus an multiplen Prozessen beteiligt, wie der Synthese von Plasmaproteinen, der Entgiftung und der Energieversorgung durch Glykogenspeicherung. Bei pathologischen Zuständen wie Sepsis, toxisch bedingtem Leberversagen oder chronischen Lebererkrankungen…
Loss of active synapses and alterations in membrane lipids are crucial events in physiological aging as well as in neurodegenerative disorders. Both are related to the abnormal aggregation of amyloid-beta (Aβ) species, generally known as amyloidosis. There are two major known human Aβ species: Aβ (1–40)…
Niemann–Pick type C1 (NPC1) is a lysosomal storage disorder, inherited as an autosomal-recessive trait. Mutations in the Npc1 gene result in malfunction of the NPC1 protein, leading to an accumulation of unesterified cholesterol and glycosphingolipids. Beside visceral symptoms like hepatosplenomegaly,…