3 Dokumente gefunden

Dual Topoisomerase Inhibitor Is Highly Potent and Improves Antitumor Response to Radiotherapy in Cervical Carcinoma †

Despite advances in vaccination and early detection, the total number of cases and deaths from cervical cancer has risen steadily in recent decades, making it the fourth most common type of cancer in women worldwide. Low-income countries in particular struggle with limited resources and treatment limitations…
Basel: Molecular Diversity Preservation International, 2025-03-21

In Vivo and In Vitro Pharmacokinetic Studies of a Dual Topoisomerase I/II Inhibitor

Due to high mortality rates, new and more effective drugs are urgently needed in cancer therapy. The novel dual topoisomerase inhibitor P8-D6, a dimethylaminoethyl-substituted pyridophenanthroline, showed in vitro impressive induction of apoptosis in tumors such as ovarian cancer or multiple myeloma…
Washington, DC: American Chemical Society, 2025-03-12

Detection of Genomic Copy Number Variations in Ovarian Cancer in the Peripheral Blood System

aus: Cancers
Simple Summary: Our research aims to test the suitability of ddPCR for the detection of tumor-related genomic imbalances (CNVs) in ovarian cancer (OC) in the peripheral blood system. In principle, in an artificial CNV simulation, we can show that CNVs can be detected even in larger dilutions in diploid…
Basel: MDPI, 2025-02-25