Major depressive disorder (MDD) is a complex psychiatric disorder that affects the lives of hundreds of millions of individuals around the globe. Even today, researchers debate if morphological alterations in the brain are linked to MDD, likely due to the heterogeneity of this disorder. The application…
Background/Objectives : Posterior tarsal tunnel syndrome is a compressive neuropathy of the tibial nerve at the level of the ankle within the tarsal tunnel. However, there is no established gold standard for the diagnosis of tarsal tunnel syndrome to date. High-resolution ultrasound could add important…
Phenotypic responses to climate affect individual fitness, but the extent to which this translates into effects on population dynamics remains poorly understood. We assemble 213 time series on phenotypes and population sizes of wild vertebrates globally and match them with local climate data. Our meta-analysis…
The understanding of how antidepressant (AD) use is associated with brain structure in individuals with major depressive disorder (MDD) remains incomplete. We aimed to examine the association between AD medication use and brain morphology in relation to age and sex by pooling structural neuroimaging…
Eosinophils are innate immune cells with central roles in allergy, parasitic diseases and multiple inflammatory conditions. Moreover, their role in host-pathogen interactions has been well characterized. However, the role of eosinophils during fungal infection is poorly defined. In this study, we delineate…
Facial muscles are uniquely attached to the skin, densely innervated, and exhibit complex co-activation patterns enabling fine motor control. Facial surface Electromyography (sEMG) effectively assesses muscle function, yet traditional setups require precise electrode placement and limit mobility due…
Abstract Purpose This study aimed to analyse COVID-19-related mortality during the pandemic, stratified by groups at risk of severe COVID-19. Methods Patients with COVID-19 between March 2020 and February 2023 were enrolled using the international multicentric Lean European Open Survey on SARS-CoV-2-Infected…
Steps Around a Theory of Action is a collection of short introductions to a series of conferences, some well-known and others hitherto unexplored, in which Gregory Bateson addressed questions related to action within the ecological crisis. The series of short texts on the conferences and the graphic…
"Gregory Bateson´s Cosmos" is an interactive graphic designed to visualize the work of Gregory Bateson and his collaboration with important personalities in a certain time period. In addition, the digital version on the homepage of the research project is linked to numerous writings and further sources.…
This article describes advancements in the ongoing digital transformation in materials science and engineering. It is driven by domainâspecific successes and the development of specialized digital data spaces. There is an evident and increasing need for standardization across various subdomains to support…
Despite advances in vaccination and early detection, the total number of cases and deaths from cervical cancer has risen steadily in recent decades, making it the fourth most common type of cancer in women worldwide. Low-income countries in particular struggle with limited resources and treatment limitations…
Background: The discovery of cellular tumor networks in glioblastoma, with routes of malignant communication extending far beyond the detectable tumor margins, has highlighted the potential of supramarginal resection strategies. Retrospective data suggest that these approaches may improve long-term disease…
Abstract Science is integral to society because it can inform individual, government, corporate, and civil society decision-making on issues such as public health, new technologies or climate change. Yet, public distrust and populist sentiment challenge the relationship between science and society. To…
In this thesis, we study evolutionary games of C. albicans within the human host, describing the fungal interactions with the human innate immune system and coexisting pathogens. Focusing on evolutionary game theory, we integrate experimental observations and theoretical modelling approaches. C. albicans…
The current generation of large language models (LLMs) has limited chemical knowledge. Recently, it has been shown that these LLMs can learn and predict chemical properties through fine-tuning. Using natural language to train machine learning models opens doors to a wider chemical audience, as field-specific…
Erschienen: The Royal Society of Chemistry, 2024-11-22
The recently much noticed Far-UVC spectral range offers the possibility of inactivating pathogens without necessarily posing a major danger to humans. Unfortunately, there are various Far-UVC sources that differ significantly in their longer wavelength UVC emission and, subsequently, in their risk potential.…
Neural networks have recently been employed as material discretizations within adjoint optimization frameworks for inverse problems and topology optimization. While advantageous regularization effects and better optima have been found for some inverse problems, the benefit for topology optimization has…
Das 2021 vom Goethe-und-Schiller-Archiv Weimar erworbene Konvolut von Protokollen der Christlich-deutschen Tischgesellschaft eröffnet neue Forschungsperspektiven: Jakob Ole Lenz fasst die publizistische Reaktion des Schriftstellers Saul Aschers auf die Gründung der Christlich-deutschen Tischgesellschaft…
Die rasche Zunahme des Klimawandels und der Umweltverschmutzung durch die massive Nutzung von Chemikalien und fossilen Brennstoffen zum Betrieb unserer Maschinen erhöht die Notwendigkeit sauberere Energiequellen in den Fokus zu nehmen. Nikola Tesla sagte einst sinngemäß: “Elektrische Energie ist überall…
Background The hepatitis E virus (HEV) can cause acute viral hepatitis with or without neurological manifestations, and occasionally progresses to chronic infection in immunocompromised individuals. The management of chronic HEV infection in cancer patients may be challenging due to the complex immunological…
