We present draft genomes of Klebsiella pneumoniae (K. pneumoniae), Enterococcus faecalis (E. faecalis), and Enterococcus faecium (E. faecium) isolated from a bilioenteric catheter after liver transplantation. Genome sizes were 5.58 Mb, 2.95 Mb, and 2.78 Mb, with G+C contents of 57.25%, 37.6%, and 37.99%,…
Washington, DC: American Society for Microbiology, 2026
Background Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder, characterized by neurocutaneous lesions. NF1 has a high degree of clinical variability, which can include multiple neoplasia as well as cutaneous, vascular, osseous, and cognitive features. When vascular involvement…
Mount Prospect, IL: Ovid Technologies (Wolters Kluwer Health), 2025-12
Zusammenfassung Hintergrund Sepsis ist eine akut lebensbedrohliche multiple Organdysfunktion, ausgelöst durch eine Infektion. Methodik Bei der vorliegenden Leitlinie handelt es sich um ein Update der S3-Leitlinie „Sepsis – Prävention, Diagnose, Therapie und Nachsorge“ (AMWF-Register-Nr.: 079–001) der…
Background The aim of this study was to investigate the preclinical biodistribution and molecular pathway of [ 68 Ga]Ga-BP-IDA and to evaluate its clinical suitability for quantitative monitoring of liver function during transarterial radioembolization (TARE) therapy of a hepatocellular carcinoma (HCC).…
DNA methylation is the most common epigenetic modification in both prokaryotic and eukaryotic genomes. Here we present a method based on highly efficient acid-hydrolysis of DNA, liquid chromatography, and detection by mass spectrometry to accurately quantify cytosine methylation in highly methylated…
Background Sepsis-induced cardiomyopathy (SIM) is characterized by myocardial dysfunction, diminished catecholamine responsiveness and worse outcomes. Hypocholesterolemia is also a well-recognized prognosticator of poor outcomes in sepsis. In vitro physiology/pharmacology studies indicate that low cholesterol…
Abstract Enterobacter cloacae complex is a group of common opportunistic pathogens on intensive care units. On intensive care units sepsis is treated with high doses of antibiotics. This treatment does not only eliminate pathogenic bacteria but parts of the microbiome community as well. This leads to…
Abstract Background The cytokine IFNγ is released primarily by lymphocytes to initiate and orchestrate immune responses in a broad range of target cells. Whereas immune cells release inflammatory mediators and initiate antimicrobial responses when stimulated by IFNγ, parenchymal cells frequently display…
Background/Objectives: Sepsis and septic shock are the most severe forms of infection. Due to the intensive cross-talk of the coagulation and immune system, coagulopathies regularly occur in sepsis. The International Society on Thrombosis and Hemostasis refers to these coagulation abnormalities as sepsis-induced…
Abstract Purpose Sepsis requires stratification for host-directed therapies through the discovery of adequate biomarkers enabling prediction of outcomes and treatment responses. Adrenomedullin has previously demonstrated potential for prognostic enrichment. This study aimed to assess associations of…
Purpose: The autonomic nervous system interacts with the immune system via the inflammatory response. Heart rate variability (HRV), a marker of autonomic activity, is associated with inflammation, and nosocomial in fections/sepsis, and has clinical implications for the monitoring of at-risk patients.…
Wissenschaftlicher Hintergrund und aktueller Forschungsstand: Die Quarantäne ist eine der effektivsten, aber auch restriktivsten Maßnahmen im Umgang mit Infektionsausbrüchen. Da ihr Erfolg davon abhängt, wie gut die Quarantäne eingehalten wird, hat die Risikokommunikation dieser Maßnahme eine hohe Bedeutung:…
Background Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals.…
Introduction Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of sepsis patients, this strategy remains insufficient for about one-third…
London: British Medical Journal Publishing Group, 2024-04-22
In vorliegender Arbeit wurden pertrochantäre Femurfrakturen durch eine anatomische Reposition mit hoher biomechanischer Stabilität mittels dynamischer Kompression durch einen Marknagel therapiert. Neben der Fraktur selbst, stellt der perioperative Blutverlust eine weitere Belastung für den Patienten…
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent form of liver disease worldwide and is linked to various chronic conditions. This dissertation investigates the role of gut microbiota in NAFLD using bioinformatics techniques, including metagenomics and metabolomics. A prospective study…
Schulteroperationen werden grundlegend in der Beach-Chair-Position (BCP) durchgeführt. Aktuelle Studien zeigen, dass die BCP einen komplikationsunabhängigen Einfluss auf den Grad der Oxygenierung im Gehirn hat. Bei Operationen an der oberen Extremität finden Regionalanästhesieverfahren, wie die interskalenäre…