The Genotype-Tissue Expression (GTEx) project provides a valuable resource for investigating gene regulation across various human tissues. However, its cross-sectional design introduces technical artifacts and batch effects related to donor demographics and tissue processing. These confounders obscure…
London: Macmillan Publishers Limited, part of Springer Nature, 2025-09-23
FoxO3a (Fork-head box O3a) is a transcription factor that regulates various cellular processes such as stress resistance, metabolism, cell-cycle arrest, and apoptosis. Modulation of stress responses by FoxO3a contributes to longevity in model organisms, such as C. elegans. Based on functional analogy…