Highlights: What are the main findings? AGE-BSA reduces EZH2 expression and the repressive histone mark H3K27me3 in proximal tubular TKPTS cells, leading to increased expression of genes involved in renal injury, including Ctgf , Snai1 , and p27 Kip1 . Pharmacological inhibition of EZH2 with DZNep mimics…
Introduction: Up to 40% of patients with typical hemolytic–uremic syndrome (HUS), characterized by microangiopathic hemolytic anemia and acute kidney injury (AKI), develop long-term consequences, most prominently chronic kidney disease (CKD). The transition from AKI to CKD, particularly in the context…
Mitochondriopathien sind das Ergebnis einer eingeschränkten mitochondrialen Funktion. Das kann vor allem in Organen mit einem hohen Energiebedarf, wie dem Herzen, zu Dysfunktionen in Form einer mitochondrialen Kardiomyopathie führen. Eine im Patienten entdeckte globale, homozygote Deletionsmutation des…
The gradual loss of kidney function due to increasing age is accompanied by structural changes such as fibrosis of the tissue. The underlying molecular mechanisms are complex, but not yet fully understood. Non-fibrillar collagen type VIII (COL8) could be a potential factor in the fibrosis processes of…
In der vorliegenden Arbeit soll untersucht werden, ob sich diese im T2DM beobachteten MORG1-Effekte auch auf den T1DM übertragen lassen und ob MORG1 eine Rolle in der Regulation des Lipidmetabolismus der Niere spielt. Des Weiteren soll überprüft werden, ob sich renoprotektive Eigenschaften des MORG1-Knockouts…
Epigenetic alterations contribute to the pathogenesis of chronic diseases such as diabetes mellitus. Previous studies of our group showed that diabetic conditions reduce the trimethylation of H3K27 in podocytes in a NIPP1- (nuclear inhibitor of protein phosphatase 1) and EZH2- (enhancer of zeste homolog…
The mitogen-activated protein kinase organizer 1 (MORG1) is a scaffold molecule for the ERK signaling pathway, but also binds to prolyl-hydroxylase 3 and modulates HIFα expression. To obtain further insight into the role of MORG1, knockout-mice were generated by homologous recombination. While Morg1+/−…
Differences between the sexes exist in many diseases, and in most cases, being a specific sex is considered a risk factor in the development and/or progression. This is not quite so clear in diabetic kidney disease (DKD), the development and severity of which depends on many general factors, such as…
Introduction: Advanced glycation end products (AGEs) are a heterogeneous group of molecules with potential pathophysiological effects on the kidneys. Fibrosis together with the accumulation of AGEs has been investigated for its contribution to age-related decline in renal function. AGEs mediate their…
Lausanne: Frontiers Research Foundation, 2023-03-29
Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to atherogenesis. We recently reported the upregulation…
Renal fatty acid (FA) metabolism is severely altered in type 1 and 2 diabetes mellitus (T1DM and T2DM). Increasing evidence suggests that altered lipid metabolism is linked to tubulointerstitial fibrosis (TIF). Our previous work has demonstrated that mice with reduced MORG1 expression, a scaffold protein…