Cationic pH‐responsive polymers promise to overcome critical challenges in cellular delivery. Ideally, the polymers become selectively charged along the endosomal pathway disturbing only the local membrane and avoiding unintended interactions or cytotoxic side effects at physiological conditions. Polypiperazines…
The efficient and safe delivery of complex biological agents offers great potential for the challenges of our time. Polymers offer considerable advantages in this regard, not only because of their low risk for immunogenic reactions, their comparatively inexpensive large-scale production and their long…
Although there has been substantial progress in the research field of gene delivery, there are some challenges remaining, e.g. there are still cell types such as primary cells and suspension cells (immune cells) known to be difficult to transfect. Cationic polymers have gained increasing attention due…