The COVID‐19 mRNA vaccines represent a milestone in developing non‐viral gene carriers, and their success highlights the crucial need for continued research in this field to address further challenges. Polymer‐based delivery systems are particularly promising due to their versatile chemical structure…
The arrangement of charged segments in triblock copolymer micelles affects the gene delivery potential of polymeric micelles and can increase the level of gene expression when an anionic segment is incorporated in the outer shell. Triblock copolymers were synthesized by RAFT polymerzation with narrow…
Washington, DC: American Chemical Society, 2024-01-17
Acrylate and acrylamide based block copolymers with cationic, anionic, hydrophilic and hydrophobic functional groups were synthesized via RAFT polymerization and assembled into micelles. The combination of different functional groups in one block copolymer composition and by mixing different (block)…
Cationic polymers have been widely studied for non-viral gene delivery due to their ability to bind genetic material and to interact with cellular membranes. However, their charged nature carries the risk of increased cytotoxicity and interaction with serum proteins, limiting their potential in vivo…