The treatment of azole-resistant Trichophyton indotineae poses a significant challenge for clinicians worldwide. Resistance mechanisms include amino acid substitutions in the sterol 14-α demethylase gene Erg11B , as well as overexpression of Erg11B . Additionally, efflux mechanisms mediated by fungal…
Azole resistance in dermatophytes, particularly Trichophyton indotineae , has become a growing global concern. Current antifungal susceptibility testing protocols (EUCAST, CLSI) have limitations in reproducibility and sensitivity. This study aimed to evaluate how medium composition, incubation temperature,…
Trichophyton ( T .) mentagrophytes ITS genotype VIII, also known as Trichophyton indotineae , is a new species of the T. mentagrophytes / T. interdigitale complex and its first records, albeit under a different species name, are from the Indian subcontinent, Middle Eastern Asia, and West Asia . T. mentagrophytes…
Trichophyton indotineae is an emerging pathogen causing recalcitrant skin infections and exhibiting multiple resistances to azoles and allylamines. Squalene epoxidase erg1 Ala448Thr mutants often show association with azole resistance. RT-PCR gene expression analysis helps to elucidate the connection…
Dermal fungal infections seem to have increased over recent years. There is further a shift from anthropophilic dermatophytes to a growing prevalence of zoophilic species and the emergence of resistant strains. New antifungals are needed to combat these fungi and their resting spores. This study aimed…