51 Dokumente gefunden
Impact of α -linolenic acid supplementation on long-chain n -3 fatty acid profiles in Western, flexitarian, vegetarian, and…
Introduction Long-chain (LC) n -3 polyunsaturated fatty acids (PUFA) are critical nutrients in vegetarian and vegan diets due to the absence of fish and other animal products. α -Linolenic acid (ALA) is the main plant derived precursor for eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and…
Lausanne: Frontiers Media, 2025-12-15
The Vitamin E Derivative Garcinoic Acid Suppresses NLRP3 Inflammasome Activation and Pyroptosis in Murine Macrophages
Excessive inflammation in cells are a common cause of inflammation-related diseases such as cardiometabolic diseases. The cellular multiprotein complex nucleotide-binding domain and leucine-rich repeat pyrin domain 3 (NLRP3) inflammasome is a cellular key modulator of inflammatory processes. In addition…
New York, NY: Springer US, 2025-10
Protein intake and cardiovascular diseases: an umbrella review of systematic reviews for the evidence-based guideline on…
Abstract Purpose This umbrella review aimed to investigate the evidence for an association of dietary intake of total protein as well as animal and plant protein with the incidence of coronary heart disease (CHD), stroke and total cardiovascular diseases (CVD). Methods PubMed, Embase and Cochrane Database…
Berlin, Heidelberg: Springer, 2025-08-13
Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases
aus: Clinical Epigenetics
Abstract Non-coding 886 ( nc886 , vtRNA2-1 ) is a polymorphically imprinted gene. The methylation status of this locus has been shown to be associated with periconceptional conditions, and both the methylation status and the levels of nc886 RNAs have been shown to associate with later-life health traits.…
London: BioMed Central, 2025-04-29
Comparative analysis of fatty acid profiles across omnivorous, flexitarians, vegetarians, and vegans : insights from the…
Abstract Background Different dietary choices can influence blood fatty acid profiles, which are crucial for maintaining physiological health and reducing disease risk. In particular, the exclusion of animal foods in vegetarian diets is associated with a higher risk of undersupply of long-chain omega…
London: BioMed Central, 2025-04-09
Reduction of cardiovascular risk factors by the diet : Evaluation of the MoKaRi concept by a parallel-designed randomized…
Abstract Background and aim The MoKaRi study aims to evaluate the impact of two nutritional concepts on cardiometabolic risk factors. Methods For our 20-week intervention study, 65 participants with moderate elevated low-density lipoprotein cholesterol (LDL-C; ≥ 3 mmol/l) and without lipid-lowering therapy…
London: BioMed Central, 2025-03-08
Einfluss des Vitamin-E-Derivats Garciniasäure auf das NLRP3-Inflammasom und die Pyroptose
Pflanzenbestandteile sind seit Jahrhunderten fester Bestandteil traditioneller Heilverfahren. In Afrika werden die Samen von Garcinia kola E. Heckel zur Behandlung entzündlicher Erkrankungen eingesetzt. Ein Isolat dieser Samen, die Garciniasäure – ein Metabolit des Vitamin-E-Kongeners δ-Tocotrienol –…
α‐Tocopherol Long‐Chain Metabolite α‐T‐13′‐COOH Exhibits Biphasic Effects on Cell Viability, Induces ROS‐Dependent DNA Damage,…
Scope The α‐tocopherol long‐chain metabolite α‐tocopherol‐13′‐hydroxy‐chromanol (α‐T‐13′‐COOH) is a proposed regulatory intermediate of endogenous vitamin E metabolism. Effects of α‐T‐13′‐COOH on cell viability and adaptive stress response are not well understood. The present study aims to investigate…
Weinheim: Wiley-VCH, 2024-12-18
Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia…
aus: Nutrients
Hypertriglyceridemia and diabetes mellitus type 2 are among the most important metabolic diseases globally. Diet plays a vital role in the development and progression of both clinical pictures. For the 10-week randomized, controlled, intervention study, 67 subjects with elevated plasma triglyceride (TG)…
Basel: MDPI, 2024-04-24
Optimized assay for the measurement of caspase‐1 expression, release, and activity in murine macrophages
aus: Applied Research
Caspase‐1 is a central component of the cellular inflammatory response, in particular with respect to its key role in the activation of the NLRP3 inflammasome pathway. Activation of caspase‐1 ensures the cleavage and release of the pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18, as well as…
Weinheim: Wiley-VCH, 2024-04-02
Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis
The mouse model of 2,4-dinitrochlorbenzene (DNCB)-induced human-like atopic dermatitis (hlAD) has been widely used to test novel treatment strategies and compounds. However, the study designs and methods are highly diverse, presenting different hlAD disease patterns that occur after sensitization and…
New York, NY: Springer US, 2024-04-02
Entwicklung und Bewertung von Ernährungskonzepten zur Prävention von Diabetes mellitus Typ II
Diabetes mellitus Typ 2 (DMT2) gehört zu den bedeutendsten Zivilisationserkrankungen der heutigen Zeit und weist seit vielen Jahren stetig ansteigende Prävalenzen auf. Bedeutsame und gleichzeitig modifizierbare Risikofaktoren für die Krankheitsentstehung sind insbesondere Übergewicht und ein ungesunder…
Entwicklung und Bewertung von Ernährungskonzepten zur Therapie einer Hypertriglyceridämie
Eine Hypertriglyceridämie definiert sich über eine Triglyceridkonzentration im Plasma oder Serum im nüchternen Zustand von ≥ 1,7 mmol/l. Etwa ein Drittel der Weltbevölkerung weist erhöhte Triglyceridkonzentrationen auf. Zusammen mit anderen Dyslipidämien stellt sie einen Risikofaktor für kardiovaskuläre…
14. Folge (01.10.2023) : Wasser: Elixier des Lebens
aus: Campusgespräch
Hinweis: Wegen einer technischen Störung ist der Abschnitt von Minute 4:12 bis Minute 4:20 leider nicht gut hörbar. Wasser wird nicht umsonst als „Lebenselixier“ bezeichnet. Denn Wasser reguliert alle wichtigen Prozesse im Körper und versorgt die Zellen mit Mineralstoffen und Spurenelementen. Zudem kann…
Jena: Friedrich-Schiller-Universität, 2023-10-01
Establishment and Characterization of Mild Atopic Dermatitis in the DNCB-Induced Mouse Model
In dermatological research, 2,4-dinitrochlorbenzene (DNCB)-induced atopic dermatitis (AD) is a standard model as it displays many disease-associated characteristics of human AD. However, the reproducibility of the model is challenging due to the lack of information regarding the methodology and the description…
Basel: Molecular Diversity Preservation International, 2023-08-01
High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography
Background Different observations have suggested that patients with depression have a higher risk for a number of comorbidities and mortality. The underlying causes have not been fully understood yet. Aims The aim of our study was to investigate the association of a genetic depression risk score (GDRS)…
Lausanne: Frontiers Media S.A., 2023-06-26
Variability in Macro- and Micronutrients of 15 Rarely Researched Microalgae
Microalgae have enormous potential for human nutrition, yet the European Commission has authorized the consumption of only eleven species. Strains of fifteen rarely researched microalgae from two kingdoms were screened regarding their nutritional profile and value for human health in two cultivation…
Basel: MDPI, 2023-06-09
α-Tocopherol-13′-Carboxychromanol Induces Cell Cycle Arrest and Cell Death by Inhibiting the SREBP1-SCD1 Axis and Causing…
α-Tocopherol-13′-carboxychromanol (α-T-13′-COOH) is an endogenously formed bioactive α-tocopherol metabolite that limits inflammation and has been proposed to exert lipid metabolism-regulatory, pro-apoptotic, and anti-tumoral properties at micromolar concentrations. The mechanisms underlying these cell…
Basel: Molecular Diversity Preservation International, 2023-05-25
Association of branched-chain amino acids with mortality-the Ludwigshafen Risk and Cardiovascular Health (LURIC) study
aus: iScience
Branched-chain amino acids (BCAAs) are effectors ofmetabolic diseases, but their impact on mortality is largely unknown.We investigated the association of BCAA with risk factors and mortality in 2,236 participants of the Ludwigshafen Risk and Cardiovascular Health (LURIC) study using linear and Cox regression.…
Amsterdam: Elsevier, 2023-04-21
Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention…
aus: Nutrients
A 14-day randomized controlled study with a parallel design was conducted with 80 healthy participants. Intervention groups I (IG1) and II (IG2) received a defined background diet and consumed a smoothie enriched with either 15 g of Chlorella dry weight (d.w.) or 15 g of Microchloropsis d.w. daily. Control…
Basel: MDPI, 2023-03-28