The hydrochalcone derivative MF-15 and the synthetically derived BRP-201 are potent anti-inflammatory active pharmaceutical ingredients (APIs) that suffer from poor bioavailability. This necessitates their incorporation into drug delivery systems. To address this limitation, we investigated four polymeric…
London: The Royal Society of Chemistry, 2025-10-16
This study demonstrates a hydrolysis‐free approach for characterizing acetalated dextran derivatives using Raman spectroscopy combined with two‐dimensional correlation spectroscopy (2D‐COS). Traditional methods like 1 H‐NMR spectroscopy rely on hydrolysis and are constrained by the time‐sensitive detection…
Polyoxazolines have long been considered as promising alternatives to poly(ethylene glycol) (PEG) due to their comparable properties, in particular regarding their stealth effect toward the immune system. Lipid nanoparticles (LNPs), as utilized, e.g., in the COVID‐19 vaccines, contain PEG‐lipids. However,…
Leukotrienes are pro-inflammatory lipid mediators generated by 5-lipoxygenase aided by the 5-lipoxygenase-activating protein (FLAP). BRP-201, a novel benzimidazole-based FLAP antagonist, inhibits leukotriene biosynthesis in isolated leukocytes. However, like other FLAP antagonists, BRP-201 fails to effectively…
Cham (ZG): Springer International Publishing, 2021-12-31