Background/Objectives: Individuals with anorexia nervosa (AN) are known to exhibit both reduced pain sensitivity—when assessed via thresholds and subjective ratings—and diminished facial expressions of emotion. Therefore, investigating the facial response to pain in this population is of particular interest.…
The human brain possesses a unique ability to switch between patterns of functional connectivity, known as brain states, which are crucial for regulating biological, cognitive, and emotional processes. These states are linked to numerous neurological and neuropsychiatric conditions, however, their relationship…
Aktuell ist Morbus Alzheimer (AD) klinisch sehr heterogen und gesichert erst post mortem diagnostizierbar, während pathologische Akkumulationen von β-Amyloid-1-42-, Tau- sowie Phospho-Tau-Protein bereits Jahrzehnte vor klinischen Symptomen auftreten. Hierdurch sind Änderungen der Fluorophore und Fluoreszenzlebensdauern…
Introduction Inhibition mechanisms are essential in daily life, helping individuals adapt to environmental demands. However, the causal interactions between large-scale functional networks involved in response inhibition remain poorly understood. Methods In this study, we examined the effective connectivity…
Lausanne: Frontiers Research Foundation, 2025-04-07
Abstract Cardiac autonomic dysfunction (CADF), mainly characterized by increased heart rate, decreased heart rate variability, and loss of vagal modulation, has been extensively described in patients with schizophrenia (SCZ) and their healthy first-degree relatives. As such, it represents an apparent…
The detection and quantification of coupling strength and direction are important aspects for achieving a deeper understanding of physiological regulatory processes in the field of network physiology. Due to the limitations of established approaches, we developed directionality indices based on simple…
Lausanne: Frontiers Research Foundation, 2025-02-13
Abstract Body image is a core identity facet in anorexia nervosa (AN). Current literature outlines body image as a multidimensional construct, characterized by perceptual, cognitive, and emotional components, which explain how individuals perceive, think, and behave in relation to their body. The purpose…
Heart rate variability (HRV) is a key indicator of cardiac autonomic function, making reliable assessment crucial. To examine the test-retest stability of resting HRV in healthy individuals, fifty participants attended two lab sessions within a week, at the same time of day. After a 5-minute acclimatization…
Mental fatigue is a significant psychopathological symptom that has recently gained attention, particularly in chronic fatigue syndrome/myalgic encephalomyelitis and Post-COVID-19 condition. However, fatigue is a clinically relevant symptom across a wide range of mental and neurological disorders. To…
Machine learning has become an important tool in precision medicine and aging research. We introduce the cardiovascular autonomic age (CAA) gap, a novel metric quantifying the deviation between machine learning-estimated biological age and chronological age based on autonomic cardiovascular function.…
Bethesda, Md.: American Physiological Society, 2025
Regular participation in sports results in a series of physiological adaptations. However, little is known about the brain adaptations to physical activity. Here we aimed to investigate whether young endurance athletes and non‐athletes differ in the gray and white matter of the brain and whether cardiorespiratory…
Die Kommunikative Bewegungstherapie (KomBT) ist ein psychotherapeutisches Gruppenverfahren, welches vorrangig in psychotherapeutischen und psychosomatischen Kliniken im Rahmen eines tiefenpsychologischen Klinikkonzepts zur Unterstützung des gruppentherapeutischen Prozesses angeboten wird. Durch den Verzicht…
A large body of literature exists on white matter (WM) abnormalities in individuals with anorexia nervosa (AN). However, these studies have primarily relied on the diffusion tensor imaging (DTI), a technique known for its limited ability to resolve complex WM fibre arrangements. To overcome limitations…
Rationale Although interest in the neurobiology of facial communication of pain has increased over the last decades, little is known about which neurotransmitter systems might be involved in regulating facial expressions of pain. Objectives We aim to investigate whether the serotonergic system (5-HT),…
Introduction: Aging is accompanied by physiological changes in cardiovascular regulation that can be evaluated using a variety of metrics. In this study, we employ machine learning on autonomic cardiovascular indices in order to estimate participants’ age. Methods: We analyzed a database including resting…
Background: Cardiac autonomic dysfunction (CADF) is a major contributor to increased cardiac mortality in schizophrenia patients. The aberrant function of voltage-gated ion channels, which are widely distributed in the brain and heart, may link schizophrenia and CADF. In search of channel-encoding genes…
Physical exercise causes marked adjustments in brain function and the cardiovascular system. Brain regions of the so-called central autonomic network (CAN) are likely to show exercise-related alterations due to their involvement in cardiac control, yet exercise-induced CAN changes remain unclear. Here…
London: Macmillan Publishers Limited, part of Springer Nature, 2022-10-06
Objective: Recent studies suggest that lower resting heart rate variability (HRV) is associated with elevated vulnerability to depressive rumination. In this study, we tested whether increases in HRV after HRV-biofeedback training are accompanied by reductions in rumination levels. Materials and methods:…
Autonomic regulation of blood pressure and cardiac rhythm progressively declines with increasing age. Impaired cardiovascular control promotes a variety of age-related cardio-vascular conditions. This study aims to provide a database of high-resolution biological signals to describe the effect of healthy…
Abstract Aging is accompanied by changes in the cardiovascular physiology that promote the development of age-related diseases. This paper presents a modern approach to quantify the physiological effects of age on the cardiovascular system by applying modern machine learning techniques to several indicators…