Abstract Purpose Elderly patients with unstable ankle fractures face a high risk of wound and implant-related complications after open reduction and internal fixation (ORIF). Less invasive intramedullary fibular nail (FN) fixation may reduce soft-tissue trauma and enable earlier mobilization. Methods…
Die Achillestendinopathie ist eine häufige Erkrankung im Leistungssport und in der Allgemeinbevölkerung. Hohes Alter, Adipositas und metabolische Erkrankungen zählen zu den Risikofaktoren, deren Bedeutung nicht abschließend geklärt ist. In der Studie wurden die Achillessehnen von 10 bzw. 100 Wochen alten…
Background: Topical NSAIDs are widely used to treat ankle sprains. Traumed (Tr14) gel is a multicomponent formulation, demonstrating inflammation-resolution properties. Methods: This multicenter, double-blind trial investigated the efficacy and safety of Tr14 gel versus placebo gel and non-inferiority…
Wie Wirbelsäule als zentrales Achsenorgan ist mit widersprüchlichen Funktionen belegt. Einerseits wird von ihm Stabilität für die Aufrechterhaltung des Rumpfes und Protektion der im Spinalkanal liegenden Strukturen geleistet. Andererseits ist die Wirbelsäule ein dynamisches Organ, welches die Beweglichkeit…
Bei zwei Drittel der Fragilitätsfrakturen des Beckens ist das Sakrum betroffen. Um ein besseres Verständnis für die Entstehung der typischen Frakturverläufe längs in den Alae und quer in den Corpora zu erlangen, wurden die zonalen Unterschiede des Kalksalzgehalts und des Fettmarkgehalts bei knochengesunden…
So far, tendon regeneration has mainly been analyzed independent from its adjacent tissues. However, the subacromial bursa in particular appears to influence the local inflammatory milieu in the shoulder. The resolution of local inflammation in the shoulder tissues is essential for tendon regeneration,…
The hook test is a widely used intraoperative method for assessing syndesmosis stability. However, there are no recommendations regarding the force required to perform this test. Furthermore, the reliability of the test is unclear. Ten experienced surgeons performed hook tests on a cadaver bone model.…
Although the rate of infection after the reconstruction of a ruptured anterior cruciate ligament (ACL) is low, prophylactic incubation of the graft with vancomycin (Vanco-wrap or vancomycin soaking) is routinely performed. A cytotoxic effect of vancomycin is reported for several cell types, and the prophylactic…
Osteomyelitis is an infection of the bone that is often difficult to treat and causes a significant healthcare burden. Staphylococcus aureus is the most common pathogen causing osteomyelitis. Osteomyelitis mouse models have been established to gain further insights into the pathogenesis and host response.…
Bone defects and infections pose significant challenges for treatment, requiring a comprehensive approach for prevention and treatment. Thus, this study sought to evaluate the efficacy of various bone allografts in the absorption and release of antibiotics. A specially designed high-absorbency, high-surface-area…
In the treatment of ankle fractures, complications such as wound healing problems following open reduction and internal fixation are a major problem. An innovative alternative to this procedure offers a more minimally invasive nail stabilization. The purpose of this biomechanical study was to clarify…
Die stabile Verankerung von Revisionsknieendoprothesen (rTKA) stellt eine große Herausforderung dar. Dies führt zu reduzierten Standzeiten im Vergleich zu Primärendoprothesen. Eine Möglichkeit zur stabileren Verankerung von rTKA stellen metaphysäre Cones und Sleeves dar. Mit dieser Arbeit soll eine aktuelle…
Objective Facing a shortage of young surgeons, this study aimed to examine the availability of mentoring programs and if this can counteract this lack. Summary background data Medical mentoring programs have proven to be decisive to influence students’ later career decisions. Since their structure may…
Chronic staphylococcal osteomyelitis can persist for long time periods causing bone destruction. The ability of Staphylococcus aureus to develop chronic infections is linked to its capacity to invade and replicate within osteoblasts and osteocytes and to switch to a dormant phenotype called small colony…
Insufficient fixation of a posterior malleolus fracture (PM) can lead to posttraumatic complications such as osteoarthritis and chronic pain. The purpose of this biomechanical study was to test the hypothesis of whether the direction of PM screw fixation has an impact on the primary stability of osteosynthesis…
Background: Tenocytes as specialised fibroblasts and inherent cells of tendons require mechanical load for their homeostasis. However, how mechanical overload compared to physiological load impacts on the tenogenic differentiation potential of fibroblasts is largely unknown. Methods: Three-dimensional…
The risk of the development of tendon disorders or ruptures increases with age, but it is unclear whether intrinsic fitness during lifetime might also affect tendon properties. To investigate this, a contrasting rat model of high-capacity runners (HCR with high intrinsic fitness) and low-capacity runners…
The subacromial bursa has long been demolded as friction-reducing tissue, which is often linked to shoulder pain and, therefore, partially removed during shoulder surgery. Currently, the discovery of the stem cell potential of resident bursa-derived cells shed a new light on the subacromial bursa. In…
Die septische Arthritis ist ein orthopädischer Notfall, der umgehende Diagnostik und Therapie erforderlich macht. Das Risiko, nach erfolgreich therapiertem Gelenkinfekt eine Arthrose zu entwickeln, ist jedoch bisher nicht hinreichend untersucht. Ziel dieser Arbeit war es deshalb, die Inzidenz und Risikofaktoren…
Old age, adiposity, and metabolic disorders are known as risk factors for chronic tendinopathy, which is a common problem in both athletes and the general population. However, the importance of these influencing factors has not yet been well understood. This study investigated alterations in gene expression…