Simple Summary This study looked at the complications that can occur following nephrectomies for kidney cancer with and without a so-called tumor thrombus, a tumor that has spread into the large vein called the inferior vena cava. So far, insufficient data are available on this topic. We developed a…
Simple Summary: In this work, we evaluated the need for frequent laboratory assessments in patients with metastatic renal cell carcinoma treated with nivolumab and nivolumab+ipilimumab during the TITAN-RCC clinical trial. We analysed how often reached criteria for dose delay or permanent discontinuation…
Simple Summary Today, most patients with metastatic renal cancer receive systemic treatment with so-called immune-checkpoint inhibitors that shall activate a patient’s immune system. For patients without prior therapy, these therapeutic agents are combined with a second immunotherapeutic drug or with…
Purpose: Therapy decision for patients with metastatic renal cell carcinoma (mRCC) is highly dependent on disease monitoring based on radiological reports. The purpose of the study was to compare non-standardized, common practice free text reporting (FTR) on disease response with reporting based on response…
Systemic therapy for metastatic renal cell carcinoma has continuously evolved over the last two decades. Significant improvements in overall survival and quality of life of patients with advanced disease have been observed. With the approval of combination therapies with PD(L)-1 immune checkpoint inhibitors…
In metastatic renal cell carcinoma (mRCC) the PD-1 immune-checkpoint inhibitor (ICI)
Nivolumab became a standard second line treatment option in 2015 based on a significant improvement
of overall survival compared to Everolimus. Current pivotal phase 3 studies showed that PD-1
ICI-based combinations…
Within this work, from a large amount of non-viral vectors available for gene transfer, some representative ones were chosen to be associated to the widely used reporter gene pCMVβGal. Polycationic bPEI, single positively charged poloxamine 304 and the non-ionic
poloxamer PE6400 were applied as polymeric…