(1) Background: Rapid microglial proliferation contributes to the complex responses of the innate immune system in the brain to various neuroinflammatory stimuli. Here, we investigated the regulatory function of phosphoinositide 3-kinase γ (PI3Kγ) and reactive oxygen species (ROS) for rapid proliferation…
Microglia, the innate immune cells of the CNS, exhibit long-term response changes indicative of innate immune memory (IIM). Our previous studies revealed IIM patterns of microglia with opposing immune phenotypes: trained immunity after a low dose and immune tolerance after a high dose challenge with…
Background: Sepsis-associated encephalopathy (SAE) is an early and frequent event of infection-induced systemic inflammatory response syndrome. Phosphoinositide 3-kinase γ (PI3Kγ) is linked to neuroinflammation and inflammation-related microglial activity. In homeotherms, variations in ambient temperature…
Neuere Untersuchungen des letzten Jahrzehnts zeigten, dass Immunzellen der angeborenen Immunabwehr in der Lage sind, Gedächtnis-ähnliche (adaptive) Reaktionen, d.h. trainierte Sensibilisierung bzw. Toleranz, auszuprägen, nachdem sie mit denselben oder verschiedenen Stressoren (PAMPs) mehrfach konfrontiert…