Akute Atemwegsinfektionen repräsentieren die häufigsten Infektionserkrankungen weltweit. Insbesondere viral-bakterielle Koinfektionen gehen mit einem ausgeprägten Mortalitätsrisiko einher. Eine besondere Bedeutung stellt die Interaktion zwischen dem Influenza-A-Virus und dem fakultativ pathogenen Bakterium…
Abstract Enterobacter cloacae complex is a group of common opportunistic pathogens on intensive care units. On intensive care units sepsis is treated with high doses of antibiotics. This treatment does not only eliminate pathogenic bacteria but parts of the microbiome community as well. This leads to…
Background Enterovirus infection has been described as a cause of severe viral sepsis in humorally immunosuppressed patients. Case presentation A 20-year-old female with a history of multiple sclerosis on ocrelizumab therapy with persistent agammaglobulinemia and autoimmune hepatitis treated with azathioprine/budesonide…
Abstract Background Alterations in the gut microbiom can significantly impact various regions in the human body, including the pulmonary tract. This study investigates alterations in the gut microbiome during a high-fat diet (HFD), particularly short-chain fatty acids (SCFAs), and how these metabolites…
A diverse bacterial community colonizes the respiratory system, including commensals such as Staphylococcus epidermidis (S. epidermidis) and Streptococcus salivarius (S. salivarius) , as well as facultative pathogens like Staphylococcus aureus (S. aureus) . This study aimed to establish a colonized cell…
Influenza A virus (IAV) infections continue to threaten public health. Current strategies, such as vaccines and antiviral drugs, are limited due to their time-consuming development and drug-resistant strains. Therefore, new effective treatments are needed. Here, virus-supportive cellular factors are…
Bakteriämien, der kulturelle Nachweis von Bakterien im Blutkreislauf, mit zusätzlich klinischen Zeichen einer Infektion stellen ein bedeutendes Gesundheitsproblem weltweit dar. Diese Infektionen können von moderaten Krankheitsverläufen bis hin zu schwerwiegenden, potenziell lebensbedrohlichen, Zuständen…
Developing effective antimicrobial biomaterials is a relevant and fast‐growing field in advanced healthcare materials. Several well‐known (e.g., traditional antibiotics, silver, copper etc.) and newer (e.g., nanostructured, chemical, biomimetic etc.) approaches have been researched and developed in recent…
Introduction: Influenza-associated pulmonary aspergillosis is associated with high mortality rates and limited treatment options. The current standard practice involves treating each pathogen separately. However, the use of antifungal drugs can lead to serious side effects, and the presence of triazole-resistant…
Rapid molecular assays can be used to identify Candida pathogens directly from positive blood cultures (BCs) in a timely manner compared to standard methods using subcultures. In this study, the eazyplex ® Candida ID assay, which is based on loop-mediated amplification (LAMP) and is currently for research…
Introduction Treatment of influenza A virus infections is currently limited to few direct acting antiviral substances. Repurposing other established pharmaceuticals as antivirals could aid in improving treatment options. Methods This study investigates the antiviral properties of ProcCluster ® and procaine…
Bei einer zunehmenden Anzahl der durchgeführten Operationen in der Knie- und Hüftendoprothetik ist trotz effektiver Präventionsmöglichkeiten mit einem Anstieg der periprothetischen Infektionen zu rechnen. Die chirurgische Hautdesinfektion führt zur weitestgehenden Destruktion der Normalflora. Es stellt…
Early identification of acute gastroenteritis (AGE) pathogens via PCR may improve the management of patients presenting to the emergency department (ED). In this study, we evaluated the implementation of a testing algorithm for ED patients with AGE using the BD MAX automated PCR system. Data from 133…
Die humorale Immunität nach einer Infektion oder Impfung gegen das Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spielt eine entscheidende Rolle bei der Eindämmung der Virusübertragung sowie der. In dieser Studie verwendeten wir einen kommerziellen Anti-Spike-IgG-Assay (S-IgG) und entwickelten…
Chronic rhinosinusitis (CRS) is a multifactorial infection of the nasal cavity and sinuses. In this study, nasal swabs from control donors (N = 128) and patients with CRS (N = 246) were analysed. Culture methods and metagenomics revealed no obvious differences in the composition of the bacterial communities…
Ziel dieser Arbeit war es, den Einfluss von Efflux, Fitness und Antibiotikaresistenz von E. coli auf den Verlauf und die Schwere der Sepsis zu erforschen. Sepsis stellt die dritthäufigste Todesursache in Deutschland dar. Zwischen 2011 und 2014 wurden im Institut für Medizinische Mikrobiologie der Uniklinik…
Methicillin-sensitive Staphylococcus ( S. ) aureus (MSSA) bacteremia remains a global challenge, despite the availability of antibiotics. Primary treatments include β-lactam agents such as cefazolin and flucloxacillin. Ongoing discussions have focused on the potential synergistic effects of combining…
Objective: Obesity is an independent risk factor for severe influenza virus and COVID-19 infections. There might be an interplay between adipose tissue and respiratory pathogens, although the mechanism is unknown. Proinflammatory factors secreted by the adipose tissue are often discussed to serve as…
As vaccination efforts against SARS-CoV-2 progress in many countries, there is still an urgent need for efficient antiviral treatment strategies for those with severer disease courses, and lately, considerable efforts have been undertaken to repurpose existing drugs as antivirals. The local anaesthetic…