Research question Do microRNAs (miRNAs) play a role in regulating endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) in decidualized cells and endometrium associated with reproductive failures? Design Endometrial stromal cell line St-T1b was decidualized in vitro with 8-Br-cAMP over…
Placenta accreta spectrum (PAS) is one of the major causes of maternal morbidity and mortality worldwide with increasing incidence. PAS refers to a group of pathological conditions ranging from the abnormal attachment of the placenta to the uterus wall to its perforation and, in extreme cases, invasion…
IL-36 cytokines (the agonists IL-36α, IL-36β, IL-36γ, and the antagonist IL-36Ra) are expressed in the mouse uterus and associated with maternal immune response during pregnancy. Here, we characterize the expression of IL-36 members in human primary trophoblast cells (PTC) and trophoblastic cell lines…
Preeclampsia constitutes a hypertensive disorder exclusive to pregnancy. It is a systemic disease with multi-organ involvement that complicates between 2 - 8% of all pregnancies, remaining one of the primary causes of maternal and perinatal morbidity and mortality in the world. Preeclampsia has been…