Vascular aging is based on the development of endothelial dysfunction, which is thought to be promoted by senescent cells accumulating in aged tissues and is possibly affected by their environment via inflammatory mediators and oxidative stress. Senescence appears to be closely interlinked with changes…
Abstract Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequences…
Endothelzellen bilden die innere Schicht von Blutgefäßen. Sie sind für die Aufrechterhaltung der vaskulären Homöostase wichtig und vermitteln Angiogenese, die durch Wachstumsfaktoren wie VEGF induziert wird und die Vaskularisierung von Geweben und Organen sichert. Voraussetzung für die Gewährleistung…