2 Dokumente gefunden

Germline variants of homology‐directed repair or mismatch repair genes in cervical cancer

While cervical cancer is associated with a persistent human papillomavirus (HPV) infection, the progression to cancer is influenced by genomic risk factors that have remained largely obscure. Pathogenic variants in genes of the homology‐directed repair (HDR) or mismatch repair (MMR) are known to predispose…
Hoboken, USA: John Wiley & Sons, Inc., 2024-08-30

Validation and functional follow‐up of cervical cancer risk variants at the HLA locus

Cervical cancer is the fourth most common cancer in females. Genome‐wide association studies (GWASs) have proposed cervical cancer susceptibility variants at the HLA locus on chromosome 6p21. To corroborate these findings and investigate their functional impact in cervical tissues and cell lines, we…
Oxford, UK: Blackwell Publishing Ltd, 2024-08-05