Background: Amatoxin-related acute liver failure (AT-ALF) carries high mortality without liver transplantation (LTX). While therapeutic plasma exchange (PEX) might improve LTX-free survival in other ALF cases, its role in AT-ALF is unclear. Clinical practice varies, and, given the rarity of this ALF…
Simple Summary The use of neoadjuvant therapies in patients with hepatocellular carcinoma prior to liver transplantation has gained increasing relevance in recent years, yet evidence regarding their impact on post-transplant outcomes remains limited. This study aimed to assess the effect of neoadjuvant…
The shortage of suitable donor organs represents an ongoing global challenge for organ transplantation. During the COVID-19 pandemic, the number of transplantable organs was especially limited. To date, the impact of recent coronavirus-19 (COVID-19) infection on liver and kidney transplant recipients…
Background: Pilonidal sinus disease (PSD) is a frequently occurring condition that can have a significant impact on quality of life (QoL). In addition to severe pain, particularly with movement or while sitting, this disease imposes restrictions that affect one’s professional and private life. These…
Purpose: The global incidence of intrahepatic cholangiocarcinoma is increasing. Surgical resection remains the gold standard treatment. However, the long-term prognosis remains dismal. The role of serum ferritin in malignant diseases has not been fully elucidated. This study aimed to evaluate the relationship…
Simple Summary This research delves into better treatment options for patients with liver cancer (HCC) who fall outside the eligibility criteria of traditional Milan guidelines for liver transplants. By reviewing patient data from Jena University spanning from 2007 to 2023, the study explores whether…
We investigated transarterial radioembolization (TARE) as a palliative measure and bridging-to-transplant therapy in hepatocellular carcinoma (HCC) patients. A total of 167 patients (50 bridging, 117 palliative) with 245 TARE procedures were assessed. Fourteen patients underwent subsequent liver transplantation…
Simple Summary The diagnosis of intrahepatic cholangiocarcinoma in a cirrhotic liver is considered a contradiction for transplantation in Germany, as well as many other international transplantation programs. The aim of our retrospective study was to evaluate the long-term outcomes of patients with incidental…
Holmium-166 microspheres are used for the transarterial radioembolization (TARE) treatment of primary and secondary liver cancers. In this study, its efficacy regarding local tumor control and integration into the oncological treatment sequence of the first 20 patients treated in our institution were…
Purpose: The survival rate of patients with irresectable perihilar cholangiocarcinoma is remarkably poor. An essential part of palliation is treatment of obstructive cholestasis caused by the tumor. Currently, this is mainly performed endoscopically by stent or via PTBD, requiring frequent changes of…
In der Arbeit findet sich eine immunhistochemische Aufarbeitung von 15 Leberadenompatienten und deren Subtypisierung. Eine immunhistochemisch Färbung wurde ebenfalls an 15 HCC und 19 FNH Patienten durchgeführt. Die Subtypen und Tumorentitäten untereinander wurden hinsichtlich klinischer und paraklinischer…
Das Auftreten einer Cholestase ist bei extrahepatischen cholangiozellulären Karzinomen häufig. Diese führt zur Leberschädigung, eingeschränkten hepatischen Regenerationskapazität und gehäuft zu einem postoperativen Leberversagen. Zur Verbesserung dieser Zustände erfolgt präoperativ oft eine Portalvenenokklusion…
Intrahepatic cholangiocarcinoma is in most transplant regions a contraindication for liver transplantation, even ruling out an active waiting list registration. However, recent studies showed that well-selected patients after a neo-adjuvant treatment benefit from liver transplantation with good long-term…
We provide a descriptive characterization of the unfolded protein response (UPR) in skeletal muscle of human patients with peritoneal sepsis and a sepsis model of C57BL/6J mice. Patients undergoing open surgery were included in a cross-sectional study and blood and skeletal muscle samples were taken.…
London: Macmillan Publishers Limited, part of Springer Nature, 2022-01-11
Die Lebertransplantation (LTx) ist ein etabliertes chirurgisches Verfahren, bei dem auch gegenwärtig überwiegend die klassische Variante mit der orthotopen Transplantation des Vollorgans eines verstorbenen Spenders (OLT) zum Einsatz kommt. Allerdings existiert seit Jahren ein Spenderorganmangel, der…
Die Ballonkyphoplastie hat sich in den letzten Jahren als Standardverfahren zur Be-handlung osteoporotischer Wirbelkörperfrakturen, vorwiegend beim älteren Patienten, etabliert. Vorteile dieser Therapieform sind die bereits in Studien nachgewiesene Schmerzreduktion sowie das minimalinvasive Vorgehen.…
Purpose: In patients suffering from autosomal dominant polycystic liver and kidney disease (ADPLKD), combined organ transplantation often poses a technical challenge due to the large volume of both organs. To simplify the transplantation procedure by improving the exposure of anatomical structures, we…
Ziel der vorliegenden Arbeit ist eine Deskription des Patientenguts, das an der Klinik für Allgemein-, Viszeral- und Gefäßchirurgie der Friedrich-Schiller-Universität Jena eine Leberteilresektion erhielt. Das zentrale Augenmerk der klinischen Nachbeobachtung galt der Morbiditäts- und Mortalitätsrate…
FDG-PET/CT-Untersuchungen erbringen eine Vielzahl relevanter Zufallsbefunde. Neben Zweitmalignomen kommen auch benigne Befunde als Malignomvorstufen und subklinische Entzündungen zur Darstellung. Bei dem untersuchten Patientenkollektiv mit HCC konnte ein Zusatznutzen der FDG-PET/CT durch die Detektion…
Background ALPPS is found to increase the resectability of primary and secondary liver malignancy at the advanced stage. The aim of the study was to verify the surgical and oncological outcome of ALPPS for intrahepatic cholangiocarcinoma (ICC). Methods The study cohort was based on the ALPPS registry…
Berlin: Springer International Publishing, 2020-05