Introduction: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, characterized by tremendous clinical heterogeneity that necessitates reliable biomarkers for the trajectory of the disease. The potential of phosphorylated Neurofilament-Heavy-chain (pNfH) measured in cerebrospinal…
Lausanne: Frontiers Research Foundation, 2025-03-12
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites. Using human skin biopsies containing sensory axons from a cohort of healthy individuals,…
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition with no cure. Biomarkers that capture the disease’s clinical heterogeneity are therefore urgently needed. This body of work aimed to characterize the biomarker profile of the chitinases, a group of immunomodulatory enzymes. We…
The pathogenesis of the fatal neurodegenerative condition amyotrophic lateral sclerosis (ALS) remains to be fully understood. Blood–brain barrier damage (BBBD) has been implicated as an exacerbating factor in several neurodegenerative conditions, including ALS. Therefore, this cross-sectional study used…