LMs derived from AA and related FAs exert diverse biological activities during inflammation. However, although discovered several decades ago, the knowledge about the regulation of the enzymes involved in LM biosynthesis remains far from completion. This thesis aimed at investigating the molecular mechanism…
In the first part, the thesis examines the influence of sex on prostanoid formation. Prostaglandins (PG) are generated by cyclooxygenase (COX)-1/2, which convert arachidonic acid (AA) to PGH2 which is further metabolized to distinct PGs by terminal synthases. Recent findings suggest a sex biased regulation…