Das C. elegans-Ortholog des humanen SELENBP1, SEMO-1, ist eine selenitbindende Methanthioloxidase (MTO), die Methanthiol zu Schwefelwasserstoff, Wasserstoffperoxid und Formaldehyd abbaut. In vivo wurde SEMO-1 als Pro-Aging-Faktor beschrieben, dessen Stilllegung die Lebensspanne verlängert. Dieser Effekt…
Cellular and organismic copper (Cu) homeostasis is regulated by Cu transporters and Cu chaperones to ensure the controlled uptake, distribution and export of Cu ions. Many of these processes have been extensively investigated in mammalian cell culture, as well as in humans and in mammalian model organisms.…
Selenium (Se) is an essential trace element for humans and animals, but high-dose supplementation with Se compounds, most notably selenite, may exert cytotoxic and other adverse effects. On the other hand, bacteria, including Escherichia coli ( E. coli ), are capable of reducing selenite to red elemental…
Methanethiol is a toxic gas produced through bacterial degradation of sulfur‐containing amino acids. Applying a novel enzymatic assay, we here identified a methanethiol oxidase (MTO) that catalyzes the degradation of methanethiol in the nematode Caenorhabditis elegans ( C. elegans ). The corresponding…