All‐aqueous, surfactant‐free, and pH‐driven nanoformulation methods to generate pH‐ and temperature‐responsive polymer nanoparticles (NPs) are described. Copolymers comprising a poly(methyl methacrylate) (PMMA) backbone with a few units of 2‐(dimethylamino)ethyl methacrylate (DMAEMA) are solubilized…