(1) Background: Since the discovery of cisplatin’s cytotoxic properties, platinum(II) compounds have attracted much interest in the field of anticancer drug development. Over the last few years, classical structure–activity relationships (SAR) have been broken by some promising new compounds based on…
(1) Background: Ruthenium and osmium complexes attract increasing interest as next generation anticancer drugs. Focusing on structure-activity-relationships of this class of compounds, we report on 17 different ruthenium(II) complexes and four promising osmium(II) analogues with cinnamic acid derivatives…
In summary, this works presents new metal(II) complexes with promising cytotoxic activity against Cisplatin resistant cell lines by following a different mechanism of action and showing higher cancer selectivity in vitro. To conclude, it was shown that asparagusic acid derivatives can coordinate to platinum(II)…