Abstract Sepsis is a dysregulated immune response to infection that can present with a pro-inflammatory endotype in which the ischemia/reperfusion injury leads to excessive production of reactive oxygen species (ROS), inflammatory mediators and the activation of cell death mechanisms. Sodium thiosulfate…
London: Macmillan Publishers Limited, part of Springer Nature, 2025-12-09
Background The aim of this study was to investigate the preclinical biodistribution and molecular pathway of [ 68 Ga]Ga-BP-IDA and to evaluate its clinical suitability for quantitative monitoring of liver function during transarterial radioembolization (TARE) therapy of a hepatocellular carcinoma (HCC).…
Background Sepsis-induced cardiomyopathy (SIM) is characterized by myocardial dysfunction, diminished catecholamine responsiveness and worse outcomes. Hypocholesterolemia is also a well-recognized prognosticator of poor outcomes in sepsis. In vitro physiology/pharmacology studies indicate that low cholesterol…
Die Leber ist als zentrales Stoffwechselorgan des Organismus an multiplen Prozessen beteiligt, wie der Synthese von Plasmaproteinen, der Entgiftung und der Energieversorgung durch Glykogenspeicherung. Bei pathologischen Zuständen wie Sepsis, toxisch bedingtem Leberversagen oder chronischen Lebererkrankungen…
Background Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals.…
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Hepatocytes are crucial for metabolic modulatory function and immunological homeostasis, where excretory liver failure, metabolic dysfunction, and dysregulated immune defence portends higher mortality.…
Die Sepsis ist eine komplexe Systemerkrankung, die durch ein Ungleichgewicht zwischen pro- und antiinflammatorischen Immunreaktionen charakterisiert ist. Dies führt über molekulare Signalkaskaden zu Gerinnungsstörungen, Durchblutungsstörungen und Perfusionsschäden, die Organschäden bis hin zum Multiorganversagen…
Background & aims: Excretory liver failure is frequently associated with poor prognosis in critically ill patients. It is characterized by the loss of canalicular membrane export pumps at the hepatocyte membrane. The membrane export pump Multidrug resistant-associated protein (MRP) 2 is pivotal in hepatocytes…
Abstract Here, we report on the development and application of a compact multi-core fiber optical probe for multimodal non-linear imaging, combining the label-free modalities of Coherent Anti-Stokes Raman Scattering, Second Harmonic Generation, and Two-Photon Excited Fluorescence. Probes of this multi-core…
London: Macmillan Publishers Limited, part of Springer Nature, 2023-08-23
Ischemia-reperfusion injury is a critical liver condition during hepatic transplantation, trauma, or shock. An ischemic deprivation of antioxidants and energy characterizes liver injury in such cases. In the face of increased reactive oxygen production, hepatocytes are vulnerable to the reperfusion driving…
Sepsis is a life-threatening condition that results from an overwhelming and disproportionate host response to an infection. Currently, the quality and extent of the immune response are evaluated based on clinical symptoms and the concentration of inflammatory biomarkers released or expressed by the…
Abstract Necroptosis facilitates cell death in a controlled manner and is employed by many cell types following injury. It plays a significant role in various liver diseases, albeit the cell-type-specific regulation of necroptosis in the liver and especially hepatocytes, has not yet been conceptualized.…
Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in metabolic, synthetic, and immunological pathways enforces limits the host's ability to control the immune response appropriately, making it vulnerable…
Abstract Background: The chemokine receptor CXCR2 and its ligands, especially CXCL8, are crucial mediators for the progression of liver inflammation and liver failure in sepsis. Neutrophils have the highest CXCR2 expression in mice and humans, and their activation via CXCL8 facilitates their migration…
Bei Cholestase kommt es zum Umbau des canaliculären Hepatozytenpols, mit Verlust des Bürstensaumes, Transporter-Internalisierung und Reorganisation des Aktinzytoskelettes. Die ERM-Proteine Ezrin, Radixin und Moesin verankern Proteine, wie das Multidrug Resistance-associated Protein 2 (MRP2) in Membranen.…
Biochemical information from activated leukocytes provide valuable diagnostic information. In this study, Raman spectroscopy was applied as a label-free analytical technique to characterize the activation pattern of leukocyte subpopulations in an in vitro infection model. Neutrophils, monocytes, and…