Background: Oral cladribine (OC) is approved for the treatment of highly active relapsing multiple sclerosis. Postmarketing safety assessments have reported rare, but occasionally severe cases of liver injury in temporal association with OC, with pathophysiologic mechanisms still unknown. In the only…
Peralkaline Sm 3+ -doped aluminosilicate glasses with different network modifier ions (Mg 2+ , Ca 2+ , Sr 2+ , Ba 2+ , Zn 2+ ) were investigated to clarify the effect of glass composition and glass structure on the optical properties of the doped Sm 3+ ions. For this purpose, the Sm 3+ luminescence emission…
Understanding the atomic structure of glasses is critical for developing new generations of materials with important technical applications. In particular, the local environment of rare-earth ions and their distribution and clustering is of great relevance for applications of rare earth-containing glasses…
Understanding the atomic structure of glasses is critical for developing new generations of materials with important technical applications. In particular, the local environment of rare-earth ions and their distribution and clustering is of great relevance for applications of rare earth-containing glasses…
Glasses with the mol% compositions 1.88 Na2O·15.04 K2O·7.52 Al2O3·69.56 SiO2·6.00 BaF2 and 1.88 Na2O·15.03 K2O·7.52 Al2O3·69.52 SiO2·6.00 BaF2·0.05 SmF3 were studied using X-ray diffraction, transmission electron microscopy, and anomalous small-angle X-ray scattering (ASAXS). While the glass doped with…
The serine/threonine protein kinase AKT1 is a downstream target of the chemokine receptor4 (CXCR4), and both proteins play a central role in the modulation of diverse cellular processes,including proliferation and cell survival. While in chronic myeloid leukemia (CML) the CXCR4is downregulated, thereby…
Ziel der vorliegenden Arbeit war die systematischeUntersuchung des zeitlich aufgelösten Fluoreszenzverhaltens von verschiedenen Seltenerdionen (Eu3+, Eu2+, Sm3+, Sm2+, Dy3+, Tb3+) in Abhängigkeit von Struktur und Zusammensetzung des verwendeten Wirtsglases und der Dotierungskonzentration des jeweiligen…