Während der kieferorthopädischen Zahnbewegung (OTM) werden im parodontalen Ligament (PdL) Bereiche mit Druck- und Zugkräften erzeugt. Mechanisch stimulierte PdL-Fibroblasten (PdLFs), der Hauptzelltyp des PdL, exprimieren signifikant erhöhte Mengen des Wachstums- und Differenzierungsfaktors 15 (GDF15).…
During orthodontic tooth movement (OTM), areas of compressive and tensile forces are generated in the periodontal ligament (PdL), a mechanoreactive connective tissue between the teeth and alveolar bone. Mechanically stimulated PdL fibroblasts (PdLFs), the main cell type of PdL, express significantly…
Periodontal ligament fibroblasts (PdLFs) exert important functions in oral tissue and bone remodeling following mechanical forces, which are specifically applied during orthodontic tooth movement (OTM). Located between the teeth and the alveolar bone, mechanical stress activates the mechanomodulatory…
The interrelationships between periodontal disease, obesity-related hyperlipidemia and mechanical forces and their modulating effects on the epigenetic profile of periodontal ligament (PdL) cells are assumed to be remarkably complex. The PdL serves as a connective tissue between teeth and alveolar bone…