Background/Objectives : The increasing use of radiopharmaceuticals in clinical practice has raised concerns regarding potential radiation exposure for healthcare personnel handling biological samples from treated patients. The objective of this study was to assess the radioactivity levels in clinically…
Background/Objectives : Biliary complications are common after liver transplantation (LT), with bile leaks representing a major cause of morbidity. Conventional imaging modalities such as ultrasound, CT, MRCP, and endoscopic techniques may fail to localize peripheral or complex leaks. This study aimed…
Ostrich eggs have recently attracted interest as an alternative model in preclinical nuclear medicine imaging. The ability to be used in clinical PET/CT (positron emission tomography/computed tomography) systems and their ethical profile are advantageous over conventional rodent models and other avian…
Abstract Purpose Synchronous esophageal (EC) and rectal carcinoma (RC) is a rare and challenging condition, particularly in curative-intended treatment. Especially locally advanced tumors may not be suitable for primary resection and require individual multimodal treatment. This review examines curative-intended…
Background: In addition to clinical examinations, confirmatory investigations are frequently performed to determine brain death (BD). Among other perfusion tests, brain perfusion scintigraphy (BPS) has been shown to be a reliable tool for the detection of brain circulatory arrest, particularly in cases…
Background The aim of this study was to investigate the preclinical biodistribution and molecular pathway of [ 68 Ga]Ga-BP-IDA and to evaluate its clinical suitability for quantitative monitoring of liver function during transarterial radioembolization (TARE) therapy of a hepatocellular carcinoma (HCC).…
Abstract Background Large-size in ovo models are receiving increasing attention since they comply with the 3R requirements (Replacement, Reduction and Refinement) by limiting the number of fully developed laboratory animals. In preclinical imaging research, a specific advantage is that they do not require…
Simple Summary Standardized ultrasound cine-loop video sequences can be seamlessly integrated into the clinical workflow, enabling the precise risk stratification of thyroid nodules via review in a PACS. The integration of additional cine loops into the clinical routine has been demonstrated to exhibit…
In-ovo imaging using ostrich eggs has been described as an alternative to animal testing using rodents. This approach is not considered an animal experiment and it does not require small-animal imaging devices as ostrich eggs provide good image quality on regular CT, MRI or PET used in humans. The aims…
A 49-year-old female presented for nuclear medicine diagnostics of a sonographically suspected parathyroid adenoma dorsal to the cranial pole of the right thyroid lobe. The patient received Tc-99m-pertechnetate and Tc-99m-sestamibi (including SPECT/CT) scans, revealing no sestamibi uptake by the suspected…
Background/Objectives : The aim of this study was to evaluate the efficacy and accuracy of PET imaging and performance in defining the preoperative TNM classification, especially the intrathoracic lymph node staging, of patients with lung cancer. Methods : A retrospective, single-institution study of…
Rationale and objectives Cervical ultrasound (US) is crucial in the follow-up of differentiated thyroid cancer (DTC). However, there are no guidelines for its acquisition and documentation, particularly concerning the role of additional video sequences, known as US cine loops (UCL). The aim of this study…
The influence of the interventional treatment approach for transarterial radioembolization (TARE) on the incidence of extrahepatic microsphere depositions and to angiographic complications was evaluated. In total, 398 TARE cycles were analyzed. Interventional treatment approaches were classified as single…
Transarterial radioembolization (TARE) with 166 Ho-loaded microspheres is an established locoregional treatment for hepatocellular carcinoma (HCC), introduced in 2010. This study evaluates the clinical outcome of patients with HCC who underwent 166 Ho-TARE with personalized dosimetry. Twenty-seven patients…
(1) Background: PSMA ligand PET/CT is increasingly important for diagnostics of prostate cancer and other tumor diseases. In particular, the radiopharmaceutical [ 68 Ga]Ga-PSMA-11 is widely used. Besides its tumor-specific binding, the uptake within the kidneys is dominant and seems to visualize the…
We investigated transarterial radioembolization (TARE) as a palliative measure and bridging-to-transplant therapy in hepatocellular carcinoma (HCC) patients. A total of 167 patients (50 bridging, 117 palliative) with 245 TARE procedures were assessed. Fourteen patients underwent subsequent liver transplantation…
Ein 83-jähriger Patient stellte sich aufgrund einer seit drei Wochen bestehenden Schwellung der Zunge vor. Die Zungenschwellung ging mit Schmerzen beim Essen, gelblichen Plaques sowie einer gräulich-braunen Läsion im vorderen Abschnitt der Zunge einher. Zusätzlich waren ein plötzlicher Sehverlust auf…
Tierversuche waren und sind heute noch ein grundlegender Bestandteil der Wissenschaft. Doch der Wunsch nach alternativen Forschungsmethoden nimmt immer mehr zu. Das In ovo-Modell ist ein Ansatz, die Zahl der Tierversuche zu verringern und den Versuchstieren unnötige Leiden zu ersparen. Bislang bedeutete…
Radionuclide cisternography (RNC) is a method for conducting imaging of the cerebrospinal system and can be used to identify cerebrospinal fluid leaks. So far, RNC has commonly employed radiopharmaceutical agents suitable only for single-photon emission tomography techniques, which are thus lacking in…
Hintergrund: Ga-68-PSMA-Ligand ist ein Radiopharmakon, welches in der PET/CT-Diagnostik von Prostatakarzinomen Anwendung findet. Es reichert sich über die Tumormanifestationen hinaus in Geweben und Organen des Körpers physiologisch an und wird über die Niere ausgeschieden. Dabei ist eine prominente renale…