Anti-NMDA receptor autoantibodies (NMDAR-Abs) in patients with NMDAR encephalitis cause severe disease symptoms resembling psychosis and cause cognitive dysfunction. After passive transfer of patients’ cerebrospinal uid or human monoclonal anti-GluN1- autoantibodies in mice, we nd a disrupted excitatory-…
Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with sepsis and increased C1q-mediated synaptic pruning in…
Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutations of ATR cause the human ATR-Seckel syndrome, characterized by microcephaly and intellectual…
Die autoimmune Enzephalitis ist eine neue Gruppe von Krankheiten die durch Autoantikörper gegen synaptische Membranproteine gekennzeichnet ist. Zum heutigen Stand sind 16 verschiedene Typen von autoimmuner Enzephalitis mit Autoantikörpern gegen postsynaptische, präsynaptische, vesikuläre und synaptische…