Abstract Introduction Patients with inflammatory rheumatic and musculoskeletal diseases (iRMD) have an increased risk of infections due to immunosuppression and autoimmune disease. While vaccinations are an important preventive strategy, vaccination coverage remains insufficient in Germany. The study…
Portal hypertension is a primary cause of complications leading to significant morbidity and mortality in patients with cirrhosis. Transjugular intrahepatic portosystemic shunt (TIPS) insertion has improved survival in well-selected patients with refractory ascites and high-risk variceal bleeding. We…
London: Macmillan Publishers Limited, part of Springer Nature, 2025-10-07
Introduction: The long-term effects of the coronavirus disease 2019 (COVID-19) are a major concern in today’s society, with cognitive impairment being an important manifestation. Notably, men and women exhibit differences in disease progression and the prevalence of long-COVID. This study aims to investigate…
Purpose Steatotic liver diseases (SLD) have become more prevalent over the last decade and are associated not only with cardiometabolic diseases but also with psychological symptoms (depression, fatigue). These symptoms are also common in post-COVID syndrome (PCS). Therefore, the aim of the study was…
Background Enterovirus infection has been described as a cause of severe viral sepsis in humorally immunosuppressed patients. Case presentation A 20-year-old female with a history of multiple sclerosis on ocrelizumab therapy with persistent agammaglobulinemia and autoimmune hepatitis treated with azathioprine/budesonide…
Aim: This article presents the study protocol of a retrospective cohort study designed to compare the effectiveness of herpes zoster, and influenza vaccines in individuals with multiple sclerosis (MS), chronic inflammatory bowel diseases (IBD), or chronic inflammatory rheumatic diseases (CIRD) to individuals…
Objectives Long-term safety is fundamental for treatment decision-making. This integrated analysis of filgotinib clinical trials in rheumatoid arthritis (RA) and ulcerative colitis (UC) assessed adverse events of interest (AEI): major adverse cardiovascular events (MACE), venous thromboembolism (VTE)…
Abstract Background A considerable number of patients who contracted SARS-CoV-2 are affected by persistent multi-systemic symptoms, referred to as Post-COVID Condition (PCC). Post-exertional malaise (PEM) has been recognized as one of the most frequent manifestations of PCC and is a diagnostic criterion…
Weltweit steigen die Erkrankungszahlen für chronisch-entzündliche Darmerkrankungen (CED) im Kindes- und Jugendalter an. Zur Behandlung dieser CEDs können TNF-alpha-Blocker wie Infliximab verabreicht werden. Zahlreiche klinische Studien richteten ihren Fokus auf Sicherheit und Wirksamkeit dieser Behandlung.…
Hintergrund: Chronisch entzündliche Darmerkrankungen (CED) mit den Hauptformen Morbus Crohn (MC) und Colitis ulcerosa (CU) entstehen auf Basis einer multifaktoriellen Genese. Neben genetischen Faktoren rücken zunehmend Umweltfaktoren in den Fokus. Vor allem wiederholte Antibiotikagaben können das Darmmikrobiom…
Abstract Objective: After infection with SARS-CoV-2, a substantial proportion of patients develop long-lasting sequelae. These sequelae include fatigue (potentially as severe as that seen in ME/CFS cases), cognitive dysfunction, and psychiatric symptoms. Because the pathophysiology of these sequelae…
Die Colitis ulcerosa (CU) ist neben dem Morbus Crohn (MC) eine der Hauptformen chronisch-entzündlicher Darmerkrankungen (CED). Das Ziel der vorliegenden Studie war es, Patienten mit aktiver Colitis ulcerosa sowohl mit FMT (Fäkaler Mikrobiom Transfer) als auch mit FMFT (Fäkaler Mikrobiom Filtrat Transfer)…
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which specific diagnostic…
Abstract Background: Clostridioides difficile ( C . difficile ) is a spore-forming bacterial species that ubiquitously exists in the environment. Colonization by C. difficile is highly prevalent in infants, while fewer than 5% of adults are asymptomatic carriers. Disruption of the microbiome, such as…
Es geht um Stuhlspende. Stuhl kann man spenden – und transplantieren. Und das kann sogar ähnlich wertvoll sein wie eine Blutspende! Am UKJ haben die Experten eine besondere Form entwickelt, um den gespendeten Stuhl auf Patientinnen und Patienten zu übertragen. Darüber sprechen Professor Andreas Stallmach,…
Hintergrund: Die Prävalenz von Patienten mit Morbus Crohn (MC) nimmt immer mehr zu. Diese chronische Entzündung kann zu Gewebeschäden mit Funktionsverlusten im gesamten Magen-Darm-Trakt führen. In der Pathogenese wird ein Ungleichgewicht antiinflammatorischer Zellen vermutet. Die gastrointestinale Mikrobiota…
Healthcare integrated biobanking describes the annotation and collection of residual samples from hospitalized patients for research purposes. The central idea of the current work is to establish an automated workflow for sample annotation, selection and storage for diabetes mellitus. This is challenging…
Abstract We report the case of a young female with steroid-dependent ulcerative colitis (UC) who developed a complex systemic infection with Aspergillus flavus . This occurred following a UC relapse while vacationing in the Middle East, leading to extended use of metamizole and subsequent agranulocytosis.…