While cervical cancer is associated with a persistent human papillomavirus (HPV) infection, the progression to cancer is influenced by genomic risk factors that have remained largely obscure. Pathogenic variants in genes of the homology‐directed repair (HDR) or mismatch repair (MMR) are known to predispose…
Background Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the host inflammation and modulate the survival in septic animals.…
Simple Summary Women treated for cervical precancers (CIN2/3) have an increased risk for recurrent lesions and therefore require post-treatment monitoring. Standard follow-up care based on hrHPV-DNA/cytology co-testing has high sensitivity but limited specificity. Host cell methylation correlates highly…
We present a calibration scheme to determine the conversion factors from a coarse-grained stochastic approximation Monte Carlo approach using the PRIME20 peptide interaction model to atomistic force-field interaction energies at full explicit aqueous solvation. The conversion from coarse-grained to atomistic…
Die Tarso-Metatarsale-I-Korrekturarthrodese ist ein häufig verwendetes Verfahren zur Korrektur eines Hallux valgus. Bezüglich Langzeitergebnissen fehlen bislang aussagekräftige Untersuchungen, auch ob diese sich von gelenkerhaltenden Verfahren mit einem vergleichbaren Indikationsspektrum in dem Maße…