Die Modellierung der menschlichen Leber in vitro ist eine anspruchsvolle Aufgabe. Jedoch sind Informationen, welche aus solcher Modelsystemen gewonnen werden können, beispielsweise über die Architektur der Leber wichtig für die Entwicklung von Arzneimitteln und die Untersuchung verschiedener Lebererkrankungen.…
LINC00174 is an example of long intergenic non-coding RNAs with important functions in the development of human cancers. The gene encoding this lincRNA is located on 7q11.21. LINC00174 has been demonstrated to play an oncogenic role in a variety of cancers, including colorectal carcinoma, thymic carcinoma,…
The Leipzig-Regensburg fault zone is documented as a band of seismic activity extending northwards from the earthquake swarm region NW-Bohemia/Vogtland at the Czech-German border area and is intersected by several Hercynian fault zones. Along the fault zone, there are several earthquake swarm areas,…
Purpose Return to a normal state of living is a key patient-relevant outcome for sepsis survivors. The Reintegration to Normal Living Index (RNLI) assesses self-perceived participation in patients with chronic disease, but its psychometric properties have been analyzed neither for patients after sepsis…
Dordrecht: Springer International Publishing, 2023-08
Hintergrund: Bandscheibenveränderungen sind in der Regel degenerativen Ursprungs und entwickeln sich über einen längeren Zeitraum. Traumatische isolierte Bandscheibenvorfälle sind selten. Jedoch beklagen Insassen von Fahrzeugen häufig nach Niedriggeschwindigkeitsunfällen einen Kausalzusammenhang zwischen…
Hintergrund: Seit mehr als 3 Jahren verursachte COVID-19 bislang weltweit fast 7 Mio. Todesfälle. Zu Beginn dieser Studie war vergleichsweise wenig über die Charakteristika dieser Patienten bekannt und vergleichende Obduktionsstudien existieren bislang kaum. Material und Methoden: Zwischen dem 11. März…
Zusammenfassung Hintergrund: In Gerichtsverfahren sollen Sachverständige häufig Stichkräfte abschätzen, welche für ein bestimmtes Verletzungsmuster erforderlich waren. Zu diesem Thema existieren nur wenige Studien. Ziele: Entwicklung und Kalibrierung eines Versuchsaufbaus zur Quantifizierung dynamischer…
In this work, attempts have been made to improve the oxidation resistance of Fe-Si alloys with 0.5, 1.0 and 2.0 mass pct Si by a preheating treatment, which was carried out at 1073 K for 24 hours in high purity hydrogen atmosphere. Compared with pure Fe and untreated Fe-Si alloys, the oxidation resistance…
Molecular communication between a pathogen and its host is crucial for a successful interplay. Extracellular vesicles (EVs) act as mediators for the delivery of molecular signals among pathogens or between pathogens and the host. Toxoplasma gondii (T. gondii), an intracellular parasite with a worldwide…
Pituitary adenomas are slow-growing tumors originated from the anterior part of pituitary gland. These tumors are associated with dysregulation of a number of long non-coding RNAs (lncRNAs). PVT1, TUG1, MALAT1, NEAT1 and GAS5 are among lncRNAs with important roles in the regulation of cell proliferation,…
Data are often subject to some degree of uncertainty, whether aleatory or epistemic. This applies both to experimental data acquired with sensors as well as to simulation data. Displaying these data and their uncertainty faithfully is crucial for gaining knowledge. Specifically, the effective communication…
Pancreatic ductal adenocarcinoma (PDAC) is a cancer that is usually diagnosed at late stages. This highly aggressive tumor is resistant to most therapeutic approaches, necessitating identification of differentially expressed genes to design new therapies. Herein, we have analyzed single cell RNA-seq…
MINCR (MYC-Induced Long Non-Coding RNA) is classified as an lncRNA. It has a significant correlation with MYC gene. MINCR has important roles in the carcinogenesis. It has been approved that this lncRNA can act as molecular sponge for miR-28-5p, miR-708-5p, miR-876-5p and miR-146a-5p. Dysregulated levels…
Non-functioning pituitary adenomas (NFPAs) are a group of pituitary tumors lacking manifestations linked to high hormone production, such as acromegaly and Cushing's syndrome. NFPA carcinogenesis depends on several molecular players. Long non-coding RNAs (lncRNAs) are a class of molecular players whose…
miRNAs represent appropriate candidates for treatment of several disorders. However, safe and efficient delivery of these small-sized transcripts has been challenging. Nanoparticle-based delivery of miRNAs has been used for treatment of a variety of disorders, particularly cancers as well as ischemic…
Purpose Mistletoe treatment is discussed controversial as a complementary treatment for cancer patients. Aim of this systematic analysis is to assess the concept of mistletoe treatment in the clinical studies with respect to indication, type of mistletoe preparation, treatment schedule, aim of treatment,…
With the increasing use of next-generation sequencing, highly effective targeted therapies have been emerging as treatment options for several cancer types. Recurrent gene-fusions have been recognized in sarcomas; however, options for targeted therapy remain scarce. Here, we describe a case of a sarcoma,…
Purpose: To determine whether the preoperative inflammatory serum C-reactive protein (CRP) and leukocyte count (LEUK) are associated with postoperative pain and complaints after otolaryngological surgery. Methods: Retrospective evaluation of 680 patients (33% female, median age 50 years) receiving otolaryngological…
Obesity is associated with alterations in brain structure and function, particularly in areas related to reward processing. Although brain structural investigations have demonstrated a continuous association between higher body weight and reduced gray matter in well-powered samples, functional neuroimaging…