000K utf8 0100 1947752146 1100 $c2025 1500 ger 2050 urn:nbn:de:gbv:27-dbt-68676-7 2051 10.22032/dbt.68676 3000 Haunhorst, Simon 4000 conceptualization of key pathophysiological mechanisms of Post-COVID Condition and their contribution to a potential interference between post-acute infection and exercise regulation [Haunhorst, Simon] 4060 141 Seiten 4209 The body’s internal milieu is regulated by interacting effector systems that aim to maintain steady states amid perturbations of homeostatic set-points. From an integrative physiology perspective, evolutionary conserved stressors, including infections and physical activity, challenge homeostasis and induce compensatory regulatory responses. In late 2019, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged as the causative pathogen of coronavirus disease 2019 (COVID-19), which can manifest with multi-systemic post-acute sequelae. Post-COVID Condition (PCC) refers to symptoms that persist for at least three months after infection, including fatigue, cognitive impairments, dyspnea, exercise intolerance and post-exertional malaise. The aim of this dissertation was to investigate key pathophysiological mechanisms of PCC and their contribution to a potential interference between post-acute infection and exercise regulation. Three comprehensive reviews of the existing literature focusing on specific entities of PCC pathophysiology were conducted. The synthesis revealed heterogenous processes underlying multi-systemic manifestations. Physical activity-related symptoms are associated with reduced aerobic capacity and impaired peripheral oxygen extraction and utilization. Microvascular alterations, erythrocyte morpho-functional changes, micro clots and impaired vascular flow-mediated dilation may compromise tissue perfusion and oxygen transport. Beyond that, mitochondrial dysfunction and a dysregulated immune system, including continued immune activation, persistent viral antigen, autoimmunity and T cell exhaustion, was identified as a central driver. Collectively, PCC is characterized by a failure to return to homeostatic conditions, resulting in continued infection regulation that interferes with physiological adaptations to physical activity and contributes to symptom exacerbation. 4950 https://doi.org/10.22032/dbt.68676$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-68676-7$xR$3Volltext$534 4961 http://uri.gbv.de/document/gvk:ppn:1947752146 5051 610 5051 796 5550 Entzündung 5550 Pathophysiologie 5550 Post-COVID-19-Syndrom 5550 Regulationsstörung 5550 Stoffwechsel 5550 Symptom 5550 Virusinfektion