nam 22 uu 4500 dbt_mods_00068571 10.3389/fnins.2025.1671341 doi dbt_mods_00068571 ger DE-601 rda eng 610 sdnb bibliography OAI Kurth, Florian Author aut School of Psychology, University of Auckland ,Auckland ,New Zealand Department of Diagnostic and Interventional Radiology, Jena University Hospital ,Jena ,Germany (DE-588)141787112 Changes in voxel-wise gray matter asymmetry over time Kurth, Florian;Cherbuin, Nicolas;Gaser, Christian;Luders, Eileen 2025-12-01 8 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zweitveröffentlichung Hemispheric brain asymmetries emerge in early life but continue to change over time. However, there is no consensus on whether asymmetries become weaker or stronger with age or which brain regions are most affected. Here, we set out to further explore age-related changes in brain asymmetry, with a particular focus on voxel-wise gray matter asymmetry. For this purpose, we selected a sample of 2,322 participants (1,150 women/1,172 men), aged between 47 and 80 years (mean 62.3 years), from the UK Biobank. Each participant was scanned twice; with an interval between baseline and follow-up scans ranging between 1 and 7 years (mean 2.4 years). Significant changes in asymmetry were observed, particularly in the temporal and occipital lobe, as well as the cerebellum. Overall, decreases in asymmetry were more prominent than increases, but with hemisphere-specific effects (i.e., leftward asymmetries decreased more than increased, while rightward asymmetries increased more than decreased). Changes in asymmetry were not significantly associated with chronological age or biological sex, suggesting that these changes neither accelerate nor decelerate with increasing age, and do not differ between the sexes. Follow-up research – potentially incorporating additional morphometric measures, different stages of life, and/or clinical populations – is necessary, not only to replicate the current findings but also to investigate changes over longer timeframes. age asymmetry brain gray matter sex article Cherbuin, Nicolas Author aut National Centre for Epidemiology and Population Health, Australian National University ,Canberra, ACT ,Australia Gaser, Christian Author aut Department of Neurology, Jena University Hospital ,Jena ,Germany Department of Psychiatry and Psychotherapy, Jena University Hospital ,Jena ,Germany German Center for Mental Health (DZPG), partner site Jena-Magdeburg-Halle ,Halle ,Germany (DE-588)123460980 Luders, Eileen Author aut School of Psychology, University of Auckland ,Auckland ,New Zealand Department of Women’s and Children’s Health, Uppsala University ,Uppsala ,Sweden Laboratory of Neuro Imaging, School of Medicine, University of Southern California ,Los Angeles, CA ,United States Friedrich-Schiller-Universität Jena Medizinische Fakultät host institution his 19:1671341 Front Neurosci Technische Universität Ilmenau, Universitätsbibliothek Frontiers in neuroscience 1662-453X dbt_mods_00029345 https://www.db-thueringen.de/receive/dbt_mods_00068571 object in context https://www.db-thueringen.de/servlets/MCRZipServlet/dbt_derivate_00069967 raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00068571.png preview https://www.db-thueringen.de/receive/dbt_mods_00068571 uri