https://www.db-thueringen.de/receive/dbt_mods_00068538https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00069925/40479_2025_Article_311.pdfhttps://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00068538.png text article Emotion-focused vs. cognitive interventions of schema therapy for borderline personality disorder effects on neural emotion regulation networks - study protocol Smesny, Stefan Smesny Stefan Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 120965240 Langbein, Kerstin Langbein Kerstin Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 112876041X article Krylova, Marina Krylova Marina Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 1268951579 Li, Meng Li Meng Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 1284122034 Izyurov, Igor Izyurov Igor Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 1348905034 Gussew, Alexander Gussew Alexander Department of Medical Physics University Hospital Halle (Saale) Halle (Saale) Germany aut Author Güllmar, Daniel Güllmar Daniel Institute of Diagnostic and Interventional Radiology, Medical Physics Group Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 136257364 Walter, Martin Walter Martin Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 136361374 urn:nbn:de:gbv:27-dbt-68538-2 Wagner, Gerd Wagner Gerd Department of Psychiatry Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 128900407 Reichenbach, Jürgen R. Reichenbach Jürgen R. Institute of Diagnostic and Interventional Radiology, Medical Physics Group Jena University Hospital Philosophenweg 3 07743 Jena Germany aut Author 172628067 10.1186/s40479-025-00311-5 2025-11-13 12 1 48 1 14 continuingjournal journal Borderline Personality Disorder and Emotion Dysregulation 2051-6673 BioMed Central London 2014 text en 150 610 Abstract Background While the effects of psychotherapy methods are being intensively researched, little is known about the clinical and neurobiological effects of specific psychotherapeutic interventions. This study examines the effects of experiential emotion-focused and cognitive interventions in schema therapy on emotion regulation in borderline personality disorder. Methods In a randomized, single-blinded, parallel group design, clinical effects and effects on resting-state functional connectivity in neural emotion regulation networks and neurotransmitter metabolism (Glx/GABA) in key regions of these networks are compared. The 9-week treatment protocol includes emotion-focused interventions such as chair dialogues, imagery rescripting, or mode role-playing in the test condition; these interventions are omitted in the active control condition (dismantling design). Resting-state functional MR imaging (rsfMRI) and MEGA-sLASER 1 H MR spectroscopy in the pregenual cingulate cortex (pgACC), anteromedial cingulate cortex (aMCC), and dorsolateral prefrontal cortex (DLPFC) are performed before and after the therapy interval and 6 months after the end of therapy and compared with the neurobiological parameters of healthy control subjects. The clinical effects are recorded using a comprehensive test battery and specified using the Reliable Change Index (RCI). Clinical and biological data are examined using mixed model analysis both longitudinally and in terms of their interactions. Discussion The aim is to show that different psychotherapeutic interventions have different effects on deficits in emotion regulation associated with specific effects on neural emotion regulation networks. This would contribute to a better understanding of the neurobiological effects and mechanisms underlying psychotherapeutic core interventions and to their more targeted use in BPD and other related disorders in the future. Trial registration ClinicalTrials.gov Identifier: NCT06367907, Retrospectively registered, April 2024. Behavioral therapy Schema therapy Borderline personality disorder Functional brain connectivity Proton MR spectroscopy Resting-state functional MR imaging Glutamate GABA en 14 Seiten 610 his Host institution bibliography Zweitveröffentlichung dbt_mods_00068538https://www.db-thueringen.de/receive/dbt_mods_00068538