@Article{dbt_mods_00066560,
  author = 	{Fuchs, Kathrin
		and D'Avanzo, Elisabetta
		and Armstark, Isabell
		and van Roey, Ruthger
		and Clavel Ezquerra, Ana
		and Bindel, Nino
		and Siebenk{\"a}s, Katharina
		and Hajjaj, Yussuf
		and Liguori, Renato
		and Ferrazzi, Fulvia
		and Amon, Lukas
		and Bulang, Johanna
		and H{\"u}bner, Julian
		and Edler, Marcel
		and Grace, Ece
		and Schwab, Annemarie
		and Alfredo, Marwin
		and Faas, Maria
		and Ackermann, Jochen
		and Percivalle, Elena
		and G{\"u}nther, Claudia
		and Hoffmann, Markus H.
		and Kr{\"o}nke, Gerhard
		and Becker, Christoph
		and Dudziak, Diana
		and Arnold, Philipp
		and Woehner, Miriam
		and Nimmerjahn, Falk
		and Brabletz, Simone
		and Stemmler, Marc P.
		and Brabletz, Thomas
		and Schuhwerk, Harald},
  title = 	{Macrophages foster anti-tumor immunity by ZEB1-dependent cytotoxic T cell chemoattraction},
  journal = 	{Communications Biology},
  year = 	{2025},
  month = 	{Jul},
  day = 	{01},
  publisher = 	{Springer Nature},
  address = 	{London},
  volume = 	{8},
  number = 	{1},
  pages = 	{1--20},
  abstract = 	{Tumor-associated macrophages (TAMs) dynamically influence anti-tumor immunity. Understanding TAM function is therefore critical to design immunotherapies. By combining syngeneic models of colorectal and pancreatic cancer with cell type-specific deletion of the epithelial-to-mesenchymal transition driver Zeb1, which is expressed in subsets of TAMs, we discovered that ZEB1 is an intrinsic regulator of TAM-controlled T cell trafficking and anti-tumor immune responses. ZEB1 supports secretion of a subset of chemokines via the constitutive pathway, including CXCL10, CCL2 and CCL22, by regulating their biosynthesis, vesicular transport and release. This elevates cytotoxic T cell (CTL) recruitment in vitro and fosters immunosurveillance by CTLs in tumors and metastases as well in an organotypic model for therapeutic CD8{\thinspace}+{\thinspace}T cell addition. Our study identifies ZEB1 in TAMs as a facilitator of anti-tumor immunity, suggests a window of opportunity for cytokine-guided CTL tropism and reinforces the importance of onco-immunological context, particularly in the design of macrophage- and/or cytokine-depleting strategies.},
  note = 	{Zweitver{\"o}ffentlichung},
  issn = 	{2399-3642},
  doi = 	{10.1038/s42003-025-08339-7},
  url = 	{https://www.db-thueringen.de/receive/dbt_mods_00066560},
  url = 	{https://doi.org/10.1038/s42003-025-08339-7},
  file = 	{:https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00068242/42003_2025_Article_8339.pdf:PDF},
  language = 	{en}
}