@PhdThesis{dbt_mods_00062655,
  author = 	{Preli{\'{c}}, Sini{\v{s}}a},
  title = 	{Non-canonical sensory biology of antennal cells in insect olfaction},
  year = 	{2024},
  address = 	{Jena},
  keywords = 	{Drosophila; Geruchssinn; Sertoli-Zelle; Glia; Sensille; Duftstoff; Nervenzelle; Signaltransduktion; Antenne <Zoologie>},
  abstract = 	{Insect olfaction is underpinned by antennae, organs featuring hair-like structures called sensilla. Sensilla are specialized compartments composed of a highly conserved cytological architecture, featuring an extracellular lymph and various neuronal and non-neuronal cells. Though the sensory contribution and olfactory roles of neuronal cells (and their olfactory receptors) is well understood, functions of non-neuronal ("support") cell types in odor detection remain poorly understood. This publication-based dissertation reviews disparate literature concerning all cell types found within insect antennae and sensilla. Here, known/unknown modes of intercellular communication are contextualized as important requisites for the sensory functionality of the multicellular and multicompartmental sensillum. Three manuscripts are presented. Manuscript I demonstrates involvement of various non-neuronal support cells during olfactory stimulation in Drosophila. Acute physiological activation of support cells is demonstrated with optical and electrophysiological techniques during the olfactory response. Manuscript II investigates nitric oxide (NO) signaling in the antenna, a ubiquitous mode of paracrine signaling. NO signaling machinery is shown to be abundant in the Drosophila antenna. Contrary to expectation, modulation of the NO-cGMP cascade is shown to have no effect on olfactory responses. Manuscript III investigates whether gap junctions directly couple cells in insect antennae, and demonstrates abundant antennal expression and cell type-specific localization of innexins, gap junction-forming genes. Potential contributions of innexins to insect olfaction are discussed. A synthesis of the emerging sensory biology of non-neuronal cells in insect antennae is presented last, with a special focus on critical remaining knowledge gaps concerning the peripheral olfactory systems of insects. Here, many novel hypotheses, concepts and considerations for future research are proposed.},
  note = 	{Dissertation, Friedrich-Schiller-Universit{\"a}t Jena, 2024},
  doi = 	{10.22032/dbt.62655},
  url = 	{https://www.db-thueringen.de/receive/dbt_mods_00062655},
  url = 	{http://uri.gbv.de/document/gvk:ppn:190386853X},
  url = 	{https://doi.org/10.22032/dbt.62655},
  file = 	{:https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00064941/Dissertation_SinisaPrelic.pdf:PDF},
  language = 	{en}
}