https://www.db-thueringen.de/receive/dbt_mods_00060428https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00063013/1-s2.0-S0925492723001464-main.pdfhttps://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00060428.png Fibre-specific white matter changes in anorexia nervosa de la Cruz, Feliberto 0000-0002-6529-2679 121628086X aut Author de la Cruz Feliberto Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC), Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital Schumann, Andy aut Author Schumann Andy Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC), Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital 1186757752 article Rieger, Katrin aut Author Rieger Katrin Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC), Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital 1302205811 Giuliano, Monica Di aut Author Giuliano Monica Di Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC), Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital 1326962833 Bär, Karl-Jürgen aut Author Bär Karl-Jürgen Lab for Autonomic Neuroscience, Imaging and Cognition (LANIC), Department of Psychosomatic Medicine and Psychotherapy, Jena University Hospital 12198169X urn:nbn:de:gbv:27-dbt-20240418-154714-003 Elsevier BV 336 111736 Psychiatry Research: Neuroimaging the official publication of the International Society for Neuroimaging in Psychiatry journal Amsterdam Elsevier 1990 en 610 1872-7506 continuingjournal text 10.1016/j.pscychresns.2023.111736 article text en 610 anorexia nervosa white matter fixel-based analysis diffusion tensor imaging A large body of literature exists on white matter (WM) abnormalities in individuals with anorexia nervosa (AN). However, these studies have primarily relied on the diffusion tensor imaging (DTI), a technique known for its limited ability to resolve complex WM fibre arrangements. To overcome limitations of DTI, this study employed fixel-based analysis (FBA) to investigate fibre-specific WM abnormalities in AN. FBA, which incorporates information on connectivity and crossing-fibres, offers greater anatomical specificity and interpretability than DTI. Twenty-six acute AN patients and thirty-one healthy controls underwent diffusion-weighted imaging scanning, and FBA and DTI metrics were compared between groups. Results revealed significant reductions in fibre-bundle cross-section within the anterior corona radiata and genu of corpus callosum, indicating morphological atrophy in AN patients. These specific tracts, identified by FBA, connect brain regions involved in the symptomatology of AN. DTI showed increased axial diffusivity in the cerebellar peduncles of AN patients but did not show significant differences in other metrics. Notably, there was no overlap between findings of FBA and DTI analyses. Overall, this study highlights the potential of FBA to detect WM abnormalities not accounted for by DTI and suggests that myelin loss contributes to the observed clinical picture in AN patients. 2023-12 6 Seiten his Host institution Zweitveröffentlichung dbt_mods_00060428https://www.db-thueringen.de/receive/dbt_mods_00060428