nam 22 uu 4500 dbt_mods_00060380 10.3390/cancers16010235 doi dbt_mods_00060380 ger DE-601 rda eng 610 sdnb Schönherr, Jacqueline Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)1334203687 Transarterial Radioembolization (TARE) in Patients with Hepatocellular Carcinoma A Comparison of Palliative with Bridging-to-Transplant Concepts Schönherr, Jacqueline;Seifert, Philipp;Gühne, Falk;Winkens, Thomas;Rauchfuß, Falk;Settmacher, Utz;Freesmeyer, Martin;Drescher, Robert;Wong, David 2024-01-04 14 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zweitveröffentlichung We investigated transarterial radioembolization (TARE) as a palliative measure and bridging-to-transplant therapy in hepatocellular carcinoma (HCC) patients. A total of 167 patients (50 bridging, 117 palliative) with 245 TARE procedures were assessed. Fourteen patients underwent subsequent liver transplantation (LT). Patients undergoing LT exhibited significantly prolonged progression-free survival (PFS) compared to those with bridging-without-transplant ( p = 0.033). No significant differences were observed between patients with bridging-without-transplant and palliative cases ( p = 0.116). Median overall survival (OS) post-TARE was 16.6 months, with estimated OS rates at 6/12 months of 82.0%/60.5%, respectively. Patients who underwent LT demonstrated statistically significantly longer OS compared to those with bridging-without-transplant ( p = 0.001). No marked outcome distinctions were found between bridging-without-transplant and palliative groups. The findings underscored the superiority of LT over alternative treatments. TARE served as an important component in non-LT scenarios, allowing for subsequent therapeutic options. The study reflected the highly variable and complex situations of patients with HCC, emphasizing the need for further investigations to define an optimal multimodal approach. liver carcinoma hepatocellular carcinoma radioembolization liver transplantation bridging therapies article Seifert, Philipp Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)1155210778 Gühne, Falk Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)1150870877 Winkens, Thomas Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)1048015599 Rauchfuß, Falk Author aut Center of Transplant Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital (DE-588)132950081 Settmacher, Utz Author aut Center of Transplant Surgery, Department of General, Visceral and Vascular Surgery, Jena University Hospital (DE-588)172370469 Freesmeyer, Martin Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)12118918X Drescher, Robert Author aut Clinic of Nuclear Medicine, Jena University Hospital (DE-588)124886361 Wong, David Editor edt Friedrich-Schiller-Universität Jena Medizinische Fakultät host institution his 16:1 Cancers (Basel) Cancers 2072-6694 dbt_mods_00040931 https://www.db-thueringen.de/receive/dbt_mods_00060380 object in context https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00062973/cancers-16-00235.pdf raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00060380.png preview https://www.db-thueringen.de/receive/dbt_mods_00060380 uri